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Is Nitrofurantoin Used For Kidney Infection

How Long Will I Take It For

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If you’re taking nitrofurantoin to:

  • treat a urinary tract infection, then you usually need to take it for 3 to 7 days
  • stop urinary tract infections coming back, you may need to take it for several months
  • prevent an infection before having surgery, you’ll usually need take it on the day of the operation and for the next 3 days

How To Take It

Swallow nitrofurantoin tablets and capsules whole. Do not chew or break them.

There’s a liquid nitrofurantoin for people who find it difficult to swallow tablets.

If you’re taking nitrofurantoin as a liquid, it’ll usually be made up for you by your pharmacist. The medicine will come with a syringe or spoon to help you take the right amount. If you do not have a syringe or spoon, ask your pharmacist for one. Do not use a kitchen teaspoon as it will not give the right amount.

The dose of nitrofurantoin you need to take depends on whether it’s being used to treat or prevent a urinary tract infection, your age, and how bad the infection is.

Antibacterial Activity And Resistance

Only 11 of the trials reported baseline resistance rates to nitrofurantoin and comparators , and only one underpowered study assessed emergence of resistance as a formal outcome. Baseline resistance was low even in earlier eras of widespread use. Likely because of nitrofurantoin’s multiple modes of action, acquisition or emergence of resistance is relatively infrequent. When it does occur, resistance is thought to be due to loss of intracellular nitroreductase activity via sequential mutations in the DNA regions encoding these enzymes., Indeed, despite several decades of use, much of it prolonged and at lower doses in the context of UTI prophylaxis, nitrofurantoin has generally retained its broad-spectrum activity against Gram-negative and Gram-positive bacteria, including most enterococci, but with the important exception of some Klebsiella strains, Pseudomonas aeruginosa and the Proteae , which carry intrinsic resistance.

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What About Cranberry Juice For Uti

Its a long-held belief that consuming cranberry juice may help prevent and treat urinary tract infections. While its true that cranberries contain an active ingredient that can prevent adherence of bacteria to the urinary tract, there is still no evidence that cranberry products can treat a UTI.

One of the reasons: Products like cranberry juice or cranberry capsules are not explicitly formulated with the same amount of PACs that have shown potential in lab studies. Moreover, a 2019 report in the Journal of Urology noted that the availability of such products to the public is a severe limitation to the use of cranberries for UTI prophylaxis outside the research setting.

In all, theres actually very little high-quality research on the topic of prevention. For instance, a 2016 study in The Journal of the American Medical Association, found that among female nursing home residents, daily consumption of cranberry capsules resulted in no significant prevention of UTIs. ;

While consuming cranberry juice or supplements is not considered a first-line treatment of urinary tract infections, in most cases, it cant hurt. After all, drinking plenty of liquids does dilute your urine and help spur more frequent urination, which flushes bacteria from the urinary tract. The exception: Those who are taking blood-thinning medication, such as warfarin, should not consume cranberry juice. And those with diabetes should be mindful of the high-sugar content of fruit juices.

Is Nitrofurantoin Safe For Breastfeeding Or People With Kidney Problems

Nitrofurantoin Dosage For UTI, Kidney Infection

Its not recommended to breastfeed on Nitrofurantoin if a baby is less than one month old. As Nitrofurantoin can pass via the breast milk.

Id talk to your doctor about other medicines that are safer to use with breastfeeding. Specifically penicillin medicines.

The same goes for people who have kidney problems as the medication can build up in the bloodstream to very high levels and other antibiotic choices may be a better fit for you.

Overall, this is really good medicine for urinary tract infections but some people cant take it for the various reasons that I mentioned before. I think it as an antibiotic that its often overlooked but its quite effective.

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More Common Side Effects

The more common side effects of nitrofurantoin can include:

  • nausea
  • very loose or watery stools
  • bloody stools
  • stomach pain
  • Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare professional who knows your medical history.

    What Are Nitrofurantoin And Bactrim

    Nitrofurantoin is an antibiotic used to treat urinary tract infections caused by several types of bacteria including E. Coli, Enterobacter cystitis, Enterococcus, Klebsiella, and Staphylococcus aureus. Nitrofurantoin interferes with the production of bacterial proteins, DNA, and cell walls. Bacteria cannot survive without a cell wall or multiply without DNA. Three forms of nitrofurantoin are available: Furadantin, a microcrystalline form; Macrodantin, a macrocrystalline; and Macrobid, a sustained release form of macrocrystalline used twice daily. The macrocrystalline form is more slowly absorbed than the microcrystalline form and is useful for patients who cannot tolerate the microcrystalline form.

    Bactrim is a combination of an antibacterial sulfonamide and a folic acid inhibitor. By combining both drugs, two important steps required in the production of bacterial proteins are interrupted, and the combination is more effective than either drug alone. Bactrim is used to treat bacterial infections including urinary tract infections, flares of chronic bronchitis due to bacteria, middle ear infections, for prevention of infections due to pneumococcus in organ transplant recipients, for the treatment or prevention of Pneumocystis cariniipneumonia, chancroid, and prevention of Toxoplasma encephalitis in patients with AIDS.

    In other persons, lung injury may occur after approximately a month of treatment. Symptoms include:

    • Difficulty breathing
    • Cough


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    What Is The Most Important Information I Should Know About Macrobid

    You should not take nitrofurantoin if you are allergic to it, or if you have:

    • severe kidney disease;
    • urination problems ; or
    • a history of jaundice or liver problems caused by taking nitrofurantoin.

    Do not take nitrofurantoin during late pregnancy .

    Tell your doctor if you have ever had:

    • kidney disease;
    • an electrolyte imbalance or vitamin B deficiency;
    • glucose-6-phosphate dehydrogenase deficiency; or
    • any type of debilitating disease.

    You should not breastfeed a baby younger than 1 month old while you are taking nitrofurantoin.

    Nitrofurantoin should not be given to a child younger than 1 month old.

    What Drugs Interact With Nitrofurantoin And Bactrim

    Nitrofurantoin – Mechanism, side effects and uses


    • High doses of probenecid or sulfinpyrazone can partially block the kidneys’ elimination of nitrofurantoin. This can increase the blood concentrations of nitrofurantoin and the risk of toxicity from nitrofurantoin.
    • Concomitant administration of a magnesium trisilicate antacid may decrease the absorption of nitrofurantoin, reducing the effectiveness of nitrofurantoin.
    • Nitrofurantoin may reduce the activity of live tuberculosisvaccine and live typhoid vaccine. In laboratory tests, nitrofurantoin reduced the effect of quinolone antibiotics, for example, norfloxacin . Therefore, nitrofurantoin should not be combined with quinolone antibiotics.


    Bactrim can enhance the blood-thinning effects of warfarin , possibly leading to bleeding.

    Sulfonamides such as sulfamethoxazole can increase the metabolism of cyclosporine , and can add to the kidney damage caused by cyclosporine.

    All sulfonamides can crystallize in urine when the urine is acidic. Since methenamine causes acidic urine, it should not be used with sulfonamides.

    Blood levels of phenytoin may be increased by treatment with Bactrim. This may lead to side effects associated with phenytoin such as dizziness, and reduced attention.

    Bactrim also may increase blood levels of digoxin and possibly lead to serious toxic effects.

    Anemia, due to a reduction in folic acid, can occur in persons receiving Bactrim in combination with:

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    Study Design And Setting

    We conducted a population-based, retrospective cohort study for the period June 2002 to March 2013 using linked health care databases in the province of Ontario, Canada. Ontario has more than 13 million residents, 15% of whom are 65 years of age or older. All residents have universal access to hospital care and physician services, and those 65 years of age or older have universal prescription drug coverage. We conducted this study at the Institute for Clinical Evaluative Sciences according to a prespecified protocol that had been approved by the institutes research ethics board. We used datasets that were held securely in linkable files without any direct patient identifiers. The reporting of this study follows guidelines for observational studies .

    Nitrofurantoin Dosage For Uti Kidney Infection

    Nitrofurantoin Dosage For UTI, Kidney Infection | Side Effects & Uses | Pregnancy:- Today Im going to answer the top eight questions I get about a medicine called Nitrofurantoin.

    Ill teach you what it is used for, what are the side effects of Nitrofurantoin, and of course how you should best take it! So lets get into it.;

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    Will A Kidney Infection Go Away With Nitrofurantn

    Ask U.S. doctors your own question and get educational, text answers â it’s anonymous and free!

    Ask U.S. doctors your own question and get educational, text answers â it’s anonymous and free!

    HealthTap doctors are based in the U.S., board certified, and available by text or video.

    Antibiotics Used For Complicated Utis

    What if Macrobid doesnât work for UTI? â KNOW & TREAT UTI

    Before getting into how to best treat a complicated UTI, its important to understand which UTIs are considered complicated. Here are some guidelines:

    • Urinary tract abnormalities are present
    • Youre pregnant
    • The patient is a child
    • A comorbidity is present that increases risk of infection or treatment resistance, such as poorly controlled diabetes
    • Youre a man, since most ;UTIs in men are considered complicated
    • Youre elderly

    Kidney infections are often treated as a complicated UTI as well, notes the Merck Manual. ;

    If a UTI is complicated, a different course of antibiotics may be required. And the initial dose of antibiotics may be started intravenously in the hospital. After that, antibiotics are given orally at home. In addition, follow-up urine cultures are generally recommended within 10 to 14 days after treatment. Not all of the antibiotics approved for uncomplicated UTIs are appropriate for the complicated version. Some that are considered appropriate, include:

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    What Is The Dosage Of Nitrofurantoin Vs Bactrim


    • The recommended adult dose for treating urinary tract infections is 50-100 mg 4 times daily or 100 mg every 12 hours for 7 days or for 3 days after obtaining sterile urine.
    • Nitrofurantoin can be taken with or without meals. Taking it with meals increases its absorption into the body.
    • The suspension can be mixed with water, milk, juice, or infant formula.
    • It also is used once a day to prevent urinary tract infections.
    • It should not be used in persons with poor kidney function.


    • The recommended adult dose for urinary tract infections is one double strength tablet or two single strength tablets every 12 hours for 10 to 14 days.
    • Flares of chronic bronchitis are treated with a similar regimen for 14 days.
    • Bactrim should be taken with 6 to 8 ounces of liquid to prevent crystals from forming in the urine. Persons with advanced kidney disease may require lower doses.

    Editorial Sources And Fact

  • R Orenstein R, Wong ES. Urinary Tract Infections in Adults. American Family Physician. March 1999.
  • Anger J, Lee U, Ackerman AL, et al. Recurrent Uncomplicated Urinary Tract Infections in Women: AUA/CUA/SUFU Guideline.;The Journal of Urology.;August 2019.
  • Patient Education: Urinary Tract Infections in Adolescents and Adults . UpToDate. January 2020.
  • Huttner A, Kowalczyk A, Turjeman A, et al. Effect of 5-Day Nitrofurantoin vs Single-Dose Fosfomycin on Clinical Resolution of Uncomplicated Lower Urinary Tract Infection in Women a Randomized Clinical Trial. Journal of the American Medical Association. May 2018.
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    Getting The Most From Your Treatment

    • Most people improve within a few days of starting treatment. If your symptoms do not improve despite taking nitrofurantoin, go back to see your doctor, as you may need an alternative antibiotic. This is because some bacteria are resistant to some types of antibiotics.
    • Nitrofurantoin can turn your urine a yellow/brown colour. This is quite harmless.
    • If you buy any medicines, check with a pharmacist that they are suitable for you to take with nitrofurantoin. Some antacids can interfere with nitrofurantoin and stop it from working properly.
    • If you are taking the contraceptive ‘pill’ at the same time as this antibiotic, the effectiveness of the ‘pill’ can be reduced if you have a bout of sickness or diarrhoea which lasts for more than 24 hours. If this should happen, ask your doctor or pharmacist for advice about what additional contraceptive precautions to use over the following few days. There is no need to use additional precautions for any bouts of sickness or diarrhoea which last for less than 24 hours.
    • If you are due to have any medical or dental treatment, tell the person carrying out the treatment that you are taking nitrofurantoin. This is because it can affect the results of some diagnostic tests.
    • Nitrofurantoin can stop the oral typhoid vaccine from working. If you are due to have any vaccinations while you are taking nitrofurantoin, please make sure the person treating you knows that you are taking it.

    Impaired Kidney Function May Not Justify Avoidance Of Nitrofurantoin


    Urinary anti-infective agents

    Bobjgalindo / Wikimedia Commons

    Nitrofurantoin is commonly used to treat urinary tract infections but is not recommended in patients with an estimated kidney glomerular filtration rate below 60ml/min/1.73m2. This advice is controversial, however, and new research suggests it may be unfounded.

    Investigators led by Amit Garg from Western University, Ontario, performed a population-based study of nearly 200,000 women who had been prescribed one of four antibiotics for a UTI. The analysis in CMAJ

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    What Causes A Kidney Infection

    Most kidney infections develop from a bladder infection . Bacteria travel up the tube between the bladder and kidney to infect a kidney. These bacteria are usually those normally living in the bowel – eg, E. coli. Most people with cystitis don’t get a kidney infection.

    Some kidney infections develop without a bladder infection. This is sometimes due to a problem in the kidney. For example, people are more prone to kidney infections if they have a kidney stone or an abnormality of the kidney.

    It is usually only one kidney that develops an infection. A kidney infection can occur at any age. It is much more common in women. This is because women are more at risk of developing a bladder infection . In women, the urethra is closer to the anus, which makes it easier for bacteria to get from the bowel to the urethra. The urethra is also shorter in women than in men, so bacteria can reach the bladder more easily.

    Kidney infections are also more common in children, in older people and during pregnancy. They are uncommon in men.

    Cautions With Other Medicines

    There are some medicines that do not mix well with nitrofurantoin.

    Tell your doctor if you’re taking these medicines before you start nitrofurantoin treatment:

    • indigestion remedies known as antacids, particularly those that contain magnesium
    • certain medicines for gout, including probenecid or sulfinpyrazone
    • cystitis remedies you can buy from a pharmacy
    • antibiotics known as quinolones, including nalidixic acid, ciprofloxacin, levofloxacin, norfloxacin, ofloxacin and moxifloxacin

    Typhoid vaccine given by mouth may not work properly if you’re taking nitrofurantoin. This does not apply to typhoid vaccines given by injection.

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    Antibiotics Used For Uncomplicated Utis

    If you are a healthy individual whose urinary tract is anatomically and functionally normal and you have no known heightened UTI susceptibility youve got whats dubbed an uncomplicated UTI, according to guidelines published;in August;2019 in the Journal of Urology. For these individuals, antibiotics are considered the first-line of treatment.

    The type of antibiotics you are prescribed and for how long is contingent on the type of bacteria detected in your urine, your current health status, and whether your UTI;is uncomplicated or complicated. Depending on which antibiotic your doctor prescribes, women may need a single dose or up to a five-day course. For men, antibiotics are usually given for a slightly longer period of time, notes UpToDate.

    Typically, if you are diagnosed with an uncomplicated UTI, one of the following will be prescribed as first-line treatment:;

    The following antibiotics are considered second-line treatments for UTI. They are generally chosen because of resistance patterns or allergy considerations:

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    How Do You Treat A Kidney Infection Without Going To The Doctor

    Antibiotics for UTI â KNOW & TREAT UTI

    Do you need to go to the doctor to treat a kidney infection? You can get your kidney infection treated without going to the doctor by seeing the doctor online instead. Youll need a prescription for antibiotics in order to treat your kidney infection, luckily you can easily get one;here;for as little at $20.

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    What Are The Serious Side Effects Of Taking Nitrofurantoin

    These are very rare, but please see your doctor if you develop shortness of breath or a persistent dry cough.

    Symptoms of liver problems including yellow skin or eyes, itching, or pale bowel motions.

    Nerve damage symptoms so specifically numbness or tingling of the fingers or toes, skin rash, or signs of allergy. Headache, changes in vision or pounding in one or both ears, or severe stomach pain.;


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