When To Consult A Doctor
If you are experiencing any of the above side effects after taking turmeric, you should stop using it. Talk to your doctor about possible replacements if you are taking curcumin supplements to complement any therapies.
Turmeric has anticoagulant properties, which means it’s a natural blood thinner. People who take Warfarin or other blood-thinning medication should be careful. The combination of turmeric and anticoagulants could result in heavy bleeding.
You should consult your doctor before taking turmeric supplements if you have:¹²
Endometriosis or uterine fibroids
More studies need to be done to reveal the efficacy of small doses of turmeric for pregnant women.
Effect Of Curcumin And Enalapril On Macrophage Infiltration
Deterioration of renal function and marked inflammation in Nx animals are associated with significant macrophage infiltration in the kidney . displays representative photomicrographs of macrophage infiltration for each experimental group, and the results are summarized in . Kidneys from control animals did not show significant macrophage infiltration, but Nx animals demonstrated prominent macrophage infiltration in the glomerulus and tubulointerstitium . Nx animals treated with curcumin and enalapril showed a reduction of macrophage influx by 53 and 43%, respectively . Although enalapril-treated animals showed a greater reduction in macrophage infiltration than curcumin-treated animals, the difference is not statistically significant.
Fig. 3.Macrophage influx in the kidney of control, sham-operated untreated 5/6 nephrectomized rat, curcumin-treated 5/6 nephrectomized rat, and enalapril-treated 5/6 nephrectomized rat. Macrophages were observed in the glomerulus and tubulointerstitium of Nx animals. A: representative photomicrographs of macrophage infiltration for each experimental group. B: macrophage influx was quantified by F4/80-positive cells. The number of macrophages was significantly decreased in Nx rats treated with curcumin and enalapril. The bar graph is the average of 4 randomly selected fields of view for each animal and expressed as total integrated optical density. Values are means ± SD n = 6 animals/group **P< 0.01, ***P< 0.001 compared with Nx.
Normally We Consume Turmeric For Its Health Benefits But Very Few Of Us Know That It Has Few Side Effects As Well
Written by Kristina Das | Published : August 8, 2018 1:19 PM IST
Turmeric is an essential ingredient in many Indian dishes. It is a popular yellow spice originating from southern Asia. Turmeric is also consumed for its health benefits but very few of us know that it has few side effects as well. Yes, turmeric, it does have side effects. And many people are concerned about the side effects of high-dose of curcumin and turmeric supplements. Here we have mentioned about few side effects of turmeric.
Too much intake of turmeric might increase the risk of kidney stones. This happens because of the presence of oxalates in turmeric. To form insoluble calcium oxalate, the oxalates can bind to calcium which is mainly responsible for kidney stones. Hence, turmeric is a strict NO for you if you have a tendency to form kidney stones.
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Why Do People Take Turmeric
Curcumin, a substance in turmeric, may help to reduce inflammation. Several studies suggest that it might ease symptoms of osteoarthritis and rheumatoid arthritis, like pain and inflammation. Other compounds in turmeric might also be medicinal.
In lab tests, curcumin seems to block the growth of certain kinds of tumors. One study showed that turmeric extract containing curcumin could — in some cases — stabilize colorectal cancer that wasn’t helped by other treatments. But more research is needed.
Other preliminary lab studies suggest that curcumin or turmeric might protect against types of colitis, stomach ulcers, and high cholesterol. Based on studies, turmeric and curcumin might also help treat upset stomach, diabetes, depression, HIV, uveitis, and viral infections.
But itâs important to keep in mind that most of these studies have been done in the laboratory. Researchers havenât yet conducted significant studies on the benefits of turmeric and curcumin. So it’s too early to say what health benefits turmeric might have.
Oranges And Orange Juice
While oranges and orange juice are arguably most well known for their vitamin C content, theyre also rich sources of potassium.
One large orange provides 333 mg of potassium. Moreover, there are 473 mg of potassium in 1 cup of orange juice .
Given their potassium content, oranges and orange juice likely need to be avoided or limited on a renal diet.
Grapes, apples, and cranberries, as well as their respective juices, are all good substitutes for oranges and orange juice, as they have lower potassium contents.
Oranges and orange juice are high in potassium and should be limited on a renal diet. Try grapes, apples, cranberries, or their juices instead.
Processed meats are meats that have been salted, dried, cured, or canned.
Some examples include hot dogs, bacon, pepperoni, jerky, and sausage.
Processed meats typically contain large amounts of salt, mostly to improve their taste and preserve flavor.
Therefore, it may be difficult to keep your daily sodium intake to less than 2,300 mg if processed meats are abundant in your diet.
Additionally, processed meats are high in protein.
If you have been told to monitor your protein intake, its important to limit processed meats for this reason as well.
Processed meats are high in salt and protein and should be consumed in moderation on a renal diet.
Pickles, processed olives, and relish are all examples of cured or pickled foods.
Usually, large amounts of salt are added during the curing or pickling process.
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Thedrugs And Supplements That Should Cause Concern
The following drugs andsupplements can affect kidney function:
NSAIDs are very effectivemedications for multiple medical problems. But taking NSAIDS can affectthe kidneys, and can cause damage, especially if youre also takingdiuretics or ACE inhibitors.
NSAIDS include over-the-counterpainkillers like aspirin , ibuprofen , and naproxen .
They also includeprescription drugs like:
- Naproxen sodium .
- Naproxen/esomeprazole .
Using these medications withcaffeine can further harm your kidneys. When taking these medications, be sureto check regularly with your doctor if you have impaired kidney function.
Certain antibiotics areremoved from the body through the kidneys, so taking them can put extra strainon your kidneys. Penicillin, cephalosporins and sulfonamides in particular canbe harmful to your kidneys.
Long-term antibiotic use caninjure your kidneys, even if youre otherwise healthy. And for people whosekidneys arent functioning at 100% to begin with, antibiotics can build up inthe body and cause damage.
Despite this, its importantto keep in mind that antibiotics can be safely used if needed as long as thedose is adjusted for your bodys level of kidney function.
3. Dietary supplements
Certain herbs or nutritionalsupplements are associated with kidney injury, even among healthy people. Withsuch a wide variety of supplements available, the best way to know if asupplement is safe is to ask your doctor to review all the ingredients.
Is Turmeric Tea Good For Kidney Disease
Turmeric tea can be helpful for kidney disease patients as it might help the kidneys in expelling out the toxic wastes from the body.
Turmeric tea may also be helpful for people suffering from polycystic kidney disease as the studies show that curcumin inhibits the growth of cyst formation in patients with PKD .
Polycystic kidney disease is an inherited disorder that can lead to the development of numerous cysts in the kidneys. The cysts are fluid-filled sacs that can cause swelling in the abdomen.
Evidence suggests that curcumin was able to demonstrate significant inhibition of the development of these fluid-filled cysts, which means it slowed down the cyst formation.
Again, a lot more further research is needed on this topic but the initial studies have indicated a positive result when it comes to turmeric and kidney diseases like PKD.
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Is It Safe To Use Herbal Supplements If I Have Kidney Disease
You may think about using herbal supplements to help with any health concerns you may have, but as a patient with kidney disease, you should use caution with herbal supplements.
Use of herbal supplements is often unsafe if you have kidney disease since some herbal products can cause harm to your kidneys and even make your kidney disease worse. Also, your kidneys cannot clear waste products that can build up in your body.
The herbal supplement market is a multi-million dollar business. You may hear from a friend or family member about an herbal supplement that they think has improved their health or well-being and they suggest it to you. While this advice may be fine for them, it can be dangerous for you with kidney disease.
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Is Curcumin Dangerous For Your Kidneys
Curcumin, which is the main component in Turmeric and has all the medicinal properties, is in general safe to ingest and would not cause any harm to your kidneys, but people who are susceptible to having kidney stones are not suggested to eat Turmeric in a lot of quantity.
This is because it has oxalates present in it in a very high amount. And is responsible for developing kidney stones. People who are already patients with kidney stones or are prone to having kidney stones should keep their turmeric intake at a minimum level. People prone to kidney stone development should take a limited amount of Turmeric ideal turmeric consumption for them will be 1-2 tablespoons a day.
Turmeric is good for kidney disease as it has Curcumin, an antioxidant and anti-inflammatory, which helps in chronic Kidney disease. Curcumin may be a helping therapy for Chronic Kidney disease patients. Given the properties of Curcumin, it can control liver diseases, digestive problems, cancer, renal diseases, etc.
Turmeric is not very helpful for health if taken alone. For gaining the complete health benefits of Turmeric, one should absorb it with cooking oil or black pepper as it increases its absorption in the body.
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Complementary Therapy For Hemodialysis Patients
People who live with chronic kidney disease require hemodialysis often. This treatment removes waste and water from your blood when your kidneys can’t do it properly. Unfortunately, hemodialysis can remove beneficial antioxidants from the patient’s body and contribute to oxidative stress.
Given turmeric’s anti-inflammatory and anti-oxidative effects, it’s possible to use it as a complementary treatment for hemodialysis patients.
Determination Of Urine Biochemical Parameters
Total urinary protein was estimated based on the method of Bradford following the manufacturers instructions , with absorbance measured at 595nm using Thermo Multiskan microplate reader. Urine creatinine and urea nitrogen were estimated using the commercial diagnostic kits following the manufacturers instructions. Creatinine clearance was mathematically calculated as a clinical index of kidney function using serum and urine creatinine values as per the following formula .
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Effect Of Curcumin On Ppre And Nf
In the earlier experiment, we observed that curcumin directly upregulated PPAR expression causing a physiological antagonism. However, curcumin might also abrogate the effect TNF- on PPAR, by interfering at the transcriptional level. The promoters of PPAR target genes consist of PPRE, a direct repeat of two hexanucleotides spaced by one nucleotide , through which PPAR can bind to and activate target gene expression . Transcription factor PPAR binds to PPRE of the target gene promoters in nucleus, leading to regulation of gene expression . To determine whether TNF- affects PPAR-mediated transactivation of PPRE, mesangial cells were transiently transfected with a PPRE-luciferase reporter construct. Twenty-four hours later, the cells were treated with TNF- in both the presence and absence of curcumin. As shown in , TNF- decreased PPRE activity by 50%, an effect which curcumin reversed in a dose dependent manner.
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Is Turmeric Bad For Your Kidneys
About 14 percent of American adults live with chronic kidney disease. Many sufferers turn to herbs for kidney failure and other renal disorders that may not respond to conventional treatment. Turmeric, for instance, may relieve some of the symptoms associated with kidney disease.
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Current evidence suggests that curcumin, the active compound in turmeric, may help slow the progression of chronic kidney disease and prevent kidney problems due to its antioxidant and anti-inflammatory properties. However, more research is needed to confirm its safety and effectiveness.
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What Are The Facts About Herbal Supplements
The following facts about herbal supplements are true for everyone, with or without kidney disease. Herbal supplements often have more than one name: a common name and a plant name. Some common concerns include:
- The Food and Drug Administration does not regulate herbal supplements for dose, content, or pureness.
- Some herbal supplements have aristolochic acid, which is harmful to kidneys.
- Herbal supplements made in other countries may have heavy metals.
- There are few studies to show if herbal supplements have real benefits and even less information in patients with kidney disease.
- Herbal supplements may interact with prescription medicines to either decrease or increase how the medicine works.
Does Too Much Turmeric Have Side Effects
Turmeric is a popular yellow spice originating from southern Asia. Its an essential ingredient in many Indian dishes.
Its also consumed for its health benefits. Supplements of turmeric, or curcumin its main active ingredient are becoming increasingly common.
However, some people are concerned about the possible side effects of high-dose turmeric and curcumin supplements. This review looks into the evidence.
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What Fruit Is Good For Kidneys
7 Kidney-Friendly Superfoods
- Apples: Apples are a good source of pectin, a soluble fiber that can lower cholesterol and glucose levels.
- Blueberries: Ranked #1 among fresh or frozen fruits and vegetables in antioxidant power, blueberries are a low-calorie source of fiber and Vitamin C.
- Great Way to Start Your Day Bagel.
- High-Protein Apple Oatmeal in a Mug.
- Microwave Coffee Cup Egg Scramble.
- No-Fuss Microwave Egg White French Toast.
Turmeric Dosage: How Much Should You Take Per Day
Turmeric supplements are now widely available for medicinal use, but knowing how much to take can be confusing.
Heres a look at the uses and benefits of turmeric, effective doses and safety concerns.
Many studies indicate that chronic, low-grade inflammation may be a key factor in developing conditions like heart disease, diabetes, Alzheimers disease and cancer .
In test-tube and animal studies, curcumin has been shown to block certain biological pathways leading to inflammation .
The effects of turmeric and curcumin have also been investigated by randomized controlled trials , the gold standard of research.
While some were inconclusive, many produced significant results.
For instance, several studies found that turmeric may reduce knee pain and improve function in people with osteoarthritis one even suggests it may work as well as ibuprofen for reducing pain .
In another RCT, 120 overweight individuals took turmeric supplements for three months. On average, total cholesterol was reduced by 32%, bad LDL cholesterol by 42% and triglycerides by 39% .
Turmeric may also improve quality of life for people with chronic kidney disease who are experiencing itchy skin. In one RCT, those taking turmeric had decreased markers of inflammation and reported less itching .
Though less conclusive, other RCTs indicate turmeric may play a beneficial role in heart disease, diabetes prevention, surgery recovery and irritable bowel syndrome .
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Medicinal Ingredient In Turmeric
The main medicinal ingredient present in Turmeric is Curcumin. It is also responsible for giving the yellow color to the food. Because of the functional compound curcumin, it was also used in the making of Chinese medicines in historic times. In India, also Turmeric has been used as an active compound in the face of Ayurveda. It has always been used for treating various diseases for thousands and thousands of years. Haldi is also a natural way to cure skin disease.
Turmeric As An Alternative Therapy For Kidney Disorders
Turmeric is a famous Indian spice that has been revered in Traditional Chinese Medicine and Ayurveda as a herb to treat almost all disorders.
Curcuminoids are a class of compounds that are found in turmeric powder which impart the yellow color to the herb and are powerful antioxidants.
Curcumin is the principal curcuminoid that contributes to most of the turmerics pharmacological properties.
Compounds found in the volatile oil fraction of turmeric also possess therapeutic properties. The research studies mentioned below explain as to how turmeric can help treat kidney disorders.
Inflammation plays a very important role in the progression of kidney disease leading to kidney failure. Inflammation is characterized by the production of pro-inflammatory chemicals and migration of white blood cells to the site of injury or infection.
Tumor necrosis factor- alpha is the principal inflammatory mediator that activates a group of proteins called nuclear factor-kappaB. NF-kappaB regulates the inflammation process.
TNF-alpha decreases the expression of protein Peroxisome proliferator-activated receptor gamma and this further accelerates inflammation.
An experimental study was conducted to evaluate the role of curcumin in treating inflammation in kidney failure. A rat model of chronic renal failure was prepared by surgical removal of kidneys in rats.
The animals were divided into three groups: untreated, curcumin-treated and enalapril-treated groups.
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Is Turmeric Good For Kidney Stones
As I mentioned above, turmeric powder is high in its oxalate content which might put people who are susceptible to developing kidney stones at risk if they have a dietary oxalate load that is already higher than it should be.
Hence, the turmeric in your diet is normally safe to eat for healthy individuals, however, if you are prone to developing kidney stones, it is important to keep an eye on the amount you consume throughout the day.
Limiting turmeric consumption to 1-2 tsp in a day would be ideal for people who are susceptible to kidney stone development.