Histamine May Protect Against Heart And Kidney Damage
New research in mice finds that histamine protects the heart and kidneys in cardiorenal syndrome.
Heart failure, or congestive heart failure, affects about people in the United States. The condition does not yet have a cure.
Chronic kidney disease also impacts a large percentage of the U.S. population, with being affected, and 47,000 cases resulting in death.
Doctors closely link the two conditions in a phenomenon they call the cardiorenal syndrome an umbrella term for several disorders that affect both the heart and kidneys.
In cardiorenal syndrome, an acute or chronic dysfunction in one organ may trigger acute or chronic dysfunction in the other, and an increasing number of studies are trying to understand why.
For instance, mounting evidence is showing that the physiological communication between heart and kidney is necessary to maintain cardiovascular homeostasis, and researchers have been using this lens to understand how chronic kidney disease raises the risk of heart failure.
Other studies have looked at the role of the sympathetic nervous system, oxidative stress, inflammation, and the so-called renin-angiotensin system in cardiorenal syndrome.
Most of these studies have looked at cardiac and renal function separately, explain the authors of the latest research, as the number of animal models that can successfully replicate dysfunction in both systems at once is insufficient.
How Will Itching In Kidney Disease Affect Your Skin
Pruritus affects everyone differently. It can range from mild to severe. Itching can be in one little place or it can ravage your entire body. Itching commonly occurs on the back, abdomen, head, and forearms.
It can occur daily and often intensifies at night. Many have reported sleeplessness because of this condition. UP usually lasts between 6 and 12 months or longer.
Diphenhydramine And Acute Kidney Injury
At the time of this writing, Dr. Scarlino was a doctor of pharmacy candidate at the university.
Michele B. Kaufman, editor of the Pharmacovigilance Forum column, is a member of P& Ts editorial board. She is President and Chief Executive Officer of PRN Communications in New York City a Pharmacist at the New YorkPresbyterian Lower Manhattan Hospital, Pharmacy Department and an Adjunct Assistant Professor at Touro College of Pharmacy in New York City.
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Cough And Cold Medicines
Many of the products available for coughs] and [colds contain a mixture of ingredients, so check the packaging carefully.
What’s safe:
Any product that contains paracetamol.
What to avoid:
Some cough and cold remedies contain high doses of aspirin, which it’s best to avoid.
Many cold remedies also contain , which you should avoid if you have high blood pressure.
The best way to clear congestion is by steam inhalation with menthol or eucalyptus. For coughs, try a simple linctus or glycerine honey and lemon to soothe your throat.
Age Of People Who Have Prostatitis When Taking Benadryl *:
- 0-1: 0.0 %
* Approximation only. Some reports may have incomplete information.
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The 10 Worst Medications For Your Kidneys
Medications that can damage the kidneys are known as nephrotoxic medications. These drugs can cause direct damage to the kidneys. Some of these medications mildly worsen kidney function and others can cause acute kidney injuries. The risk for kidney damage depends on your individual health and other medications you are taking. For people with even mild kidney failure, you might want to talk to your doctor about the pros and cons of these medications.
Are Antihistamines Bad For Your Prostate
Antihistaminesthe prostateAntihistamines
. Similarly one may ask, does Claritin affect your prostate?
Second-generation antihistamines do not carry a prostate warning and would perhaps be a better choice for patients with allergic rhinitis who have BPH. Both can affect the prostate, and there is no other nonprescription option.
what is the best medicine for enlarged prostate? There are several treatment options for an enlarged prostate. You can take alpha-blockers such as terazosin or tamsulosin to help relax the prostate and bladder muscles. You can also take dutasteride or finasteride , a different kind of medication for reducing BPH symptoms.
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. , such as pseudoephedrine , are used to treat congestion often associated with a cold. These drugs, which are called vasopressor adrenergics, worsen BPH symptoms because they tighten muscles in the prostate and bladder neck.
Can medication affect your prostate?
Antihistamines and decongestants may add to the problem. These drugs can make it harder for the prostate and the bladder to relax, making it even more difficult for urine to flow.
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Chinese/herbal Medicines And Vitamin Supplements
Chinese/herbal medicines and vitamin supplements have not usually been studied in people with kidney disease, so there is no way of knowing whether they are safe for you to use. Modern drugs go through rigorous tests of their effectiveness and purity. But some Chinese and herbal remedies have been found to contain substances that may cause kidney failure and cancer, while others contain substances that interfere with the effectiveness of your other medicines.
Antihistamine Side Effects You Should Know
Like most allergy sufferers, I rely on medication to manage my symptoms. But antihistamine side effectssome of which may be unexpectedcan make taking these drugs a complex experience. Of course, all drugs come with the risk for some side effects, and even with those side effects, the benefits of taking a medication may still be worth it. But its always better not to be surprised by them.
Im something of an antihistamine connoisseur, you might say. In my decades-long quest to stop sneezing at seemingly every green thing outside, Ive taken pretty much every over-the-counter antihistamine out there, as well as a few prescription ones. And during that journey, Ive learned that some medications make me extremely sleepy while others dry my mouth out so much I spend the day chugging La Croix. Sometimes its just the price you have to pay for a day without eyes swollen shut!
In one particularly memorable episode, a friends adorable and very friendly Australian shepherd licked my neck while at a picnic in the park. I broke out in hives, popped a Benadryl, and spent the second half of the afternoon sound asleep in the grass while my friends carried on their party around me.
All of this is to say that, as much as I love and depend on the effects of antihistamines, you have to know what youre getting into when you take themespecially with regards to their potential side effects.
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Could Otc Antihistamines Cause Problems With Any Other Medicines I Take
Antihistamines can interact with other medicines you take. Talk to your doctor before taking a first-generation antihistamine if you take any medicines that can make you tired. These include sleeping pills, sedatives, or muscle relaxants.
Antihistamines are often combined with decongestants and/or pain relievers. If you take a combination medicine, its important to know each active ingredient. One or more could interact with other medicines youre taking.
Be sure not to take too much antihistamine. Many OTC cold and allergy medicines contain them already. Some prescription medicines do, too. If you take more than 1 of these medicines, you may get much more antihistamine than is good for you. Second-generation antihistamines are less likely to interact with other medicines you are taking. Always talk to your doctor if you take other medicines to make sure they are safe.
Cetirizine 10 Mg Film
Cetirizine 10 mg Film-Coated Tablets
PATIENT INFORMATION LEAFLET: INFORMATION FOR THE USER
Cetirizine 10 mg film-coated tablets
Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.
This medicine is available without prescription.
However, you still need to use Cetirizine 10 mg Tablets carefully to get the best results from it.
- Keep this leaflet. You may need to read it again.
- If you have any further questions, ask your doctor or pharmacist.
- You must contact a doctor if your symptoms worsen or do not improve after 3 days.
- If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.
- In this leaflet Cetirizine 10 mg film-coated tablets will be called Cetirizine 10 mg Tablets
What is in this leaflet:
1. What Cetirizine 10 mg Tablets are and what they are used for2. What you need to know before you take Cetirizine 10 mg Tablets3. How to take Cetirizine 10 mg Tablets4. Possible side effects5. How to store Cetirizine 10 mg Tablets6. Contents of the pack and other information
1. WHAT CETIRIZINE 10 MG TABLETS ARE AND WHAT THEY ARE USED FOR
Cetirizine hydrochloride is the active ingredient of Cetirizine 10 mg Tablets.
Cetirizine 10 mg Tablets is an antiallergic medication.
In adults and children aged 6 year and above, Cetirizine 10 mg Tablets are indicated
2. WHAT YOU NEED TO KNOW BEFORE YOU TAKE CETIRIZINE 10 MG TABLETS
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What Should I Avoid While Taking Diphenhydramine
Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.
Drinking alcohol can increase certain side effects of diphenhydramine.
Ask a doctor or pharmacist before using any other medicine that may contain diphenhydramine. This includes medicines for sleep, cold/allergy symptoms, or anti-itch medicine used on the skin. Using too much diphenhydramine may lead to a fatal overdose.
Are There Any Potential Side Effects
The most common side effect is lethargy, dry mouth, and urinary retention. Vomiting, diarrhea, and lack of appetite are also possible. Excitement rather than lethargy can occur occasionally, especially in cats. Diphenhydramine can alter the results of skin allergy testing discontinue this medication at least 2 weeks before testing.
This short-acting medication should stop working within 24 hours, although effects can be longer in pets with liver or kidney disease.
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Alternate Treatments That Wont Affect The Prostate
Vapor rubs using topical preparations containing camphor, menthol, eucalyptus and other aromatic oils may be applied to the neck and chest at bedtime or vaporized in a machine during sleeping hours. There is some evidence that the use of aroma therapy can help relieve symptoms of the common cold. Vapor therapy does not cause urinary difficulties.
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Antihistamine Risks And Anticholinergic Syndrome
The first H1 sedating antihistamines have been available for more than 60 years and were synthesized based on a chemical structure similar to that used to develop cholinergic muscarinic antagonists, tranquilizers, and antihypertensive agents. These antihistamines have low receptor specificity and interact with both peripheral and central histamine receptors and readily cross the blood-brain barrier. This leads to significant central nervous system side effects, including sedation, drowsiness, somnolence, fatigue, cognitive decline, psychomotor effects, and loss of coordination.
These antihistamines also are potent muscarinic receptor antagonists that can lead to serious anticholinergic side effects, such as sinus tachycardia, dry skin, dry mucous membranes, dilated pupils, constipation, ileus, urinary retention, and agitated delirium.3 The mnemonic blind as a bat, dry as a bone, red as a beet, mad as a hatter, and hot as a hare often is used to help describe and identify patients suffering from anticholinergic syndrome .
| Anticholinergic Syndrome Mnemonic |
| Confusion, deliriumHyperthermia |
Urinary retention and difficulty urinating can be particularly troublesome in male patients with enlarged prostates, and this retention can increase the risk of urinary tract infections, especially in women.4
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How Long Does It Take For Benadryl To Get Out Of Your System
For the average healthy adult, elimination half-life ranges from 6.7 to 11.7 hours. So between 6 to 12 hours after taking Benadryl, half the drug will be eliminated from the body. Within two days, the drug will be completely gone from the body.
Prostate And Kidney Precautions With Nonprescription Products
W. Steven Pray, PhD, DPhBernhardt Professor, Nonprescription Products and DevicesCollege of Pharmacy
Gabriel E. Pray, PharmD CandidateCollege of PharmacyWeatherford, Oklahoma
US Pharm
When patients ask for assistance with selection of an appropriate nonprescription product, it is vital for the pharmacist to be aware of the various label precautions and warnings. Several groups of products present potential problems for patients with a history of kidney disease or prostate enlargement.
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How Is Chronic Urinary Retention Diagnosed
History and physical exam: During the diagnosis process, your healthcare provider will ask about your signs and symptoms and how long you have had them. He or she will also ask about your medical history and your drug use. A physical exam of the lower abdomen may show the cause or give your provider additional clues. After this, certain tests may be needed. Men may have a rectal exam to check the size of their prostate.
Your urine may be saved and checked to look for infection.
Ultrasound of the bladder: The amount of urine that stays in your bladder after urinating may be measured by doing an ultrasound test of the bladder. This test is called a postvoid residual or bladder scan.
Cystoscopy: Cystoscopy is a test in which a thin tube with a tiny camera on one end is put into your urethra. This lets the doctor look at pictures of the lining of your urethra and bladder. This test may show a stricture of the urethra, blockage caused by a stone, an enlarged prostate or a tumor. It can also be used to remove stones, if found. A computed tomography scan may also help find stones or anything else blocking the flow of urine.
Urodynamic testing: Tests that use a catheter to record pressure within the bladder may be done to tell how well the bladder empties. The rate at which urine flows can also be measured by such tests. This is called urodynamic testing.
Limited Fluid Intake Due To Renal Disease
Some patients have kidney damage that forces them to limit their fluid intake to prevent fluid overload. If you have this problem, you should avoid nonprescription products that must be taken with a lot of fluid so you can get them down. This includes bowel regulation products containing psyllium and methylcellulose.
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Is It Harmful To Take Benadryl Every Night
Taking Benadryl to help you get to sleep is okay in small doses once in a while but, again, it doesnt lead to better quality sleep, Elliott said. Because antihistamines can peer pressure your body to spend more time in the lighter stages of sleep, the eight hours you clock in bed might end up feeling more like five.
What Is Itching In Kidney Disease
Uraemic pruritus or uremic pruritus is a fancy way of saying itching in kidney disease. This condition occurs in those who have chronic kidney disease . There is incessant pruritus, or itch that occurs all over the body.
CKD-associated pruritus often occurs during end-stage renal disease . Also referred to as renal failure is the final stage of CKD when kidney function has declined to the point that the kidneys can no longer function on their own.
Those with ESRD will need dialysis treatment since the kidneys are no longer able to filter the blood.
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Can Allergy Medications Harm Your Brain
It’s allergy season and many of us will be reaching into the medicine cabinet for relief. But it is important to choose wisely, as some allergy medications can harm brain health and increase dementia risk.
Diphenhydramine is a first-generation antihistamine medication . In addition to treating allergy and cold symptoms such as sneezing and watery eyes, it also blocks the actions of acetylcholine. This is a neurotransmitter that is important for brain functions including learning and memory. Diphenhydramine is classified as an anticholinergic drug, and a study of this class of drug found that increased use is associated with an up to 54% increased risk of dementia .
SAFER ALTERNATIVES
The good news is that newer antihistamines equal the effectiveness of diphenhydramine with few or no cognitive side effects. These medications were developed to minimize adverse events common to diphenhydramine and other older antihistamines .
If you’re older or have concerns about brain health, consider an allergy medication other than diphenhydramine. In addition to the medications above, topical nasal sprays and allergy shots are available by prescription and can also help alleviate symptoms. As always, it’s a good idea to discuss your options with a medical professional.
Urinary Tract And Kidney Warnings On Nonprescription Products
W. Steven Pray, PhD, DPhBernhardt Professor, Nonprescription Products and DevicesCollege of Pharmacy
Edmond, Oklahoma
US Pharm.
Pharmacists are in a unique position with regard to counseling about OTC products. They can explore the various warnings and precautions on a products label to help patients decide when a product is inappropriate and a physician should be consulted, a process called pharmacist-assisted self-care triage. Many nonprescription products carry warnings related to the urinary tract, and knowledge of those products and the rationale for the warnings can help pharmacists provide the highest level of care.
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