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How Does Lisinopril Affect Your Kidneys

Who Should Avoid Lisinopril

Keeping Kidneys Safe – Know How Medicines Affect the Kidneys

Lisinopril is safe for the vast majority of patients. However, pregnant or nursing mothers, patients with a history of angioedema, and people with high potassium levels should avoid this medication.

People with kidney or liver disease may need to avoid taking Lisinopril or be monitored carefully by a physician.

  • Pregnant or nursing mothers should avoid taking Lisinopril.
  • Those with angioedema or with a history of angioedema shouldnt take Lisinopril.
  • Patients with kidney problems may need to avoid Lisinopril or receive careful monitoring..
  • People with liver disease may need to avoid Lisinopril.
  • Those with high blood-potassium levels shouldnt take Lisinopril.

Dosage For Acute Myocardial Infarction

Adult dosage

  • Starting dosage: 5 mg taken by mouth within the first 24 hours of when symptoms of heart attack start. Your doctor will give you another 5 mg after another 24 hours.
  • Usual dosage: 10 mg given 48 hours after heart attack. Then 10 mg taken once per day for at least 6 weeks.

Child dosage

This medication hasnt been studied and shouldnt be used in children younger than 18 years for improving survival after a heart attack.

Senior dosage

There are no specific recommendations for senior dosing. Older adults may process drugs more slowly. A normal adult dose may cause levels of this drug to be higher than normal in your body. If youre a senior, you may need a lower dose or a different schedule.

What Does Lisinopril Do

Lisinopril is an angiotensin converting enzyme inhibitor. Lisinopril competitively binds to and inhibits angiotensin converting enzyme , thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Lisinopril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.

Like other ACE inhibitors, lisinopril relaxes and widens the blood vessels. This lowers your blood pressure and makes it easier for your heart to pump blood around your body. This can improve the symptoms of heart failure.

In diabetic kidney disease, lisinopril helps to protect your kidneys and slows down the disease. Lisinopril does this by reducing the amount of protein you lose through your kidneys and by reducing high blood pressure.

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Check Blood Pressure As Recommended By Your Healthcare Provider

Lisinopril lowers blood pressure. To make sure the drug is working and to prevent blood pressure from getting too low, purchase a blood pressure monitor and check blood pressure regularly. Watch for signs of low blood pressure such as dizziness, lightheadedness, and fainting. Call a healthcare provider if any of these side effects are experienced.

Lisinopril Oral Tablet And Other Medications

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Below is a list of medications that can interact with lisinopril oral tablet. This list does not contain all drugs that may interact with lisinopril oral tablet.

Before taking lisinopril oral tablet, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

You should not take lisinopril with the drug sacubitril, which is found in sacubitril/valsartan . Taking sacubitril/valsartan with lisinopril may raise your risk for angioedema, which is severe, sudden swelling that forms under your skin.

People taking lisinopril who have diabetes should not take aliskiren with lisinopril. Taking these drugs together raises your risk for side effects from either drug, especially in people with diabetes.

Medications that can interact with lisinopril include:

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Warnings For Other Groups

For pregnant women: This drug can have a negative impact on the development of a fetus. Lisinopril should only be used during pregnancy in serious cases where its needed to treat a dangerous condition in the mother.

Talk with your doctor if youre pregnant or planning to become pregnant. Ask your doctor to tell you about the specific harm that may be done to the fetus. This drug should be only used if the potential risk to the fetus is acceptable given the drugs potential benefit.

For women who are breastfeeding: It isnt known if this drug passes into breast milk. If it does, it may cause side effects in a child who is breastfed. Talk with your doctor if you breastfeed your baby. You may need to decide whether to stop breastfeeding or stop taking this medication.

For seniors: Older adults may process drugs more slowly. A normal adult dose may cause levels of this drug to be higher than normal in your body. If youre a senior, you may need a lower dose or a different schedule.

For children: This medication hasnt been studied and shouldnt be used in children younger than 6 years.

For Black patients: This medication may not work as well to lower blood pressure in Black patients. Your doctor may have you take another drug with lisinopril. If you have any questions, talk with your doctor.

What To Do In Case You Take Too Much Lisinopril Oral Tablet

If you think youve taken too much of this drug, call your doctor. You can also call the American Association of Poison Control Centers at 800-222-1222 or use their online tool. But if your symptoms are severe, call 911 or your local emergency number, or go to the nearest emergency room right away.

This drug comes with several precautions.

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Can Lisinopril Interact With Grapefruit

No, lisinopril doesnt interact with grapefruit.

Depending on the condition youre using lisinopril to treat, other drugs you take with lisinopril may interact with grapefruit. For example, after a heart attack, most people are also prescribed a statin, which is a medication that lowers your cholesterol. Some statins interact with grapefruit. Your doctor or pharmacist can check for any interactions between the statin youre prescribed and grapefruit.

If you have other questions about whether grapefruit interacts with any medications you take, talk with your doctor or pharmacist.

Are There Things I Shouldnt Eat Or Drink While Taking An Ace Inhibitor

How Does Smoking Affect Your Kidneys?

In general, follow your healthcare providers guidance when it comes to what you should or shouldnt eat or drink. This is especially true if your provider tells you to follow a low-sodium diet. Not following that guidance could affect your sodium levels. You also should avoid salt substitutes that contain potassium until you talk to your provider about whether or not those substitutes are safe.

While it isn’t dangerous, capsaicin the chemical compound that makes foods like peppers spicy can sometimes worsen an ACE inhibitor-related cough.

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The Need To Monitor Kidney Function With Certain Drugs

Experts have suggested that after the initial assessment of kidney function, physicians should consider regular monitoring after starting or increasing the dosage of drugs associated with nephrotoxicity, especially those used chronically in patients with multiple risk factors for impaired kidney function, Dr. Naughton noted. If there is any sign of kidney harm, the provider should review the medications you are taking in order to identify which one is causing the problem.

If multiple medications are present and the patient is clinically stable, physicians should start by discontinuing the drug most recently added to the patients medication regimen. Once that has been taken care of, further harm to the kidneys may be minimized by keeping blood pressure stable, staying hydrated, and temporarily avoiding the use of other medications that may cause nephrotoxicity.

These safety tips can ensure you get the care you need while keeping your kidneys safe. That way, they can tend to essential functions like keeping things flowing .Originally published May 11, 2017

How To Use Lisinopril Oral

Take this medication by mouth with or without food as directed by your doctor, usually once daily.

If you are using the suspension form of this medication, shake the bottle well before each dose. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

The dosage is based on your medical condition and response to treatment. For children, the dosage is also based on weight.

To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor’s instructions carefully.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Keep taking this medication even if you feel well. Most people with high blood pressure do not feel sick.

For the treatment of high blood pressure, it may take 2 to 4 weeks before you get the full benefit of this medication. For the treatment of heart failure, it may take weeks to months before you get the full benefit of this medication. Tell your doctor if your condition does not get better or if it gets worse .

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Lisinopril Oral Tablet Interactions

Lisinopril oral tablet can interact with several other medications. It can also interact with certain supplements.

Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works. Other interactions can increase side effects or make them more severe.

Medications That Can Harm The Kidneys

High Blood Pressure Meds And Kidney Disease

No matter what kind of medicine you take, whether OTC or prescription, it is destined to take a trip through your kidneys. Taking a drug the wrong way or in excessive amounts can damage these vital, bean-shaped organs and lead to serious complications. In the worst-case scenario, it could necessitate a kidney transplant.

Compared with 30 years ago, patients todayhave a higher incidence of diabetes and cardiovascular disease, take multiple medications, and are exposed to more diagnostic and therapeutic procedures with the potential to harm kidney function, according to Cynthia A. Naughton, PharmD, senior associate dean and associate professor in the department of pharmacy practice at North Dakota State University. All of these factors are associated with an elevated risk of kidney damage.

An estimated 20% of cases of acute kidney failure are due to medications. The technical term for this scenario is nephrotoxicity, which is growing more common as the aging population grows, along with rates of various diseases.

The kidneys get rid of waste and extra fluid in the body by filtering the blood to produce urine. They also keep electrolyte levels balanced and make hormones that influence blood pressure, bone strength and the production of red blood cells. When something interferes with the kidneys, they cant do their job, so these functions can slow down or stop altogether.

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How To Take Lisinopril

This dosage information is for lisinopril oral tablet. All possible dosages and forms may not be included here. Your doctor will tell you what dosage is right for you. Your dose, form, and how often you take it will depend on:

  • your age
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What Conditions Are Treated By This Class Of Medication

ACE inhibitors can treat the following conditions:

  • Prevention of heart attack and stroke in people at high risk for either.
  • Preventing and slowing the progression of kidney failure in people with diabetes.

ACE inhibitors also treat several kidney diseases in people who dont have diabetes, including:

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Lisinopril Oral Tablet Use With Other Drugs

Depending on the condition its prescribed to treat, you may use lisinopril alone or with other drugs.

For example, for treating hypertension , you may take lisinopril alone. But in some cases, your doctor may also prescribe another blood pressure medication that works differently than lisinopril, such as hydrochlorothiazide. For some people, using more than one drug works better to treat high blood pressure.

For treating heart failure and for reducing the risk of dying after a heart attack, lisinopril is used with other drugs. Medications commonly used with lisinopril for treating heart failure include beta-blockers, and diuretics. Medications commonly used with lisinopril after a heart attack include beta-blockers, statins, and blood thinners.

If you have questions about using lisinopril with other drugs, talk with your doctor.

Lisinopril Oral Tablet And Pregnancy

Lisinopril: Precautions for Use

Lisinopril oral tablets are not safe to use while pregnant. This is because drugs such as lisinopril can cause harm to a fetus or miscarriage if used during pregnancy.

Lisinopril has a boxed warning about this effect. This is the most serious warning from the Food and Drug Administration . A boxed warning alerts doctors and patients about drug effects that may be dangerous.

For this reason, you should not take lisinopril while pregnant, and you should stop taking lisinopril if you become pregnant during your treatment. If youre pregnant or planning to become pregnant, talk with your doctor about safer options for treating your condition.

If you become pregnant while taking lisinopril, its very important that you tell your doctor right away. Theyll have you stop taking the drug, and they can recommend other treatments instead.

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Watch For Signs Of Angioedema

Angioedema is swelling of the tissues under the skin. Its similar to hives but the swelling is deeper and usually doesnt itch. Angioedema is often an allergic reaction, but lisinopril can cause angioedema by the way it works in the body. Angioedema is a serious and potentially life-threatening medical problem. If it gets too severe, it can block airways and cause death by asphyxiation. Get immediate medical attention at any sign of angioedema such as:

  • Swelling of the face, lips, tongue, or throat
  • Trouble breathing or swallowing

Lisinopril And Hydrochlorothiazide May Cause Side Effects Tell Your Doctor If Any Of These Symptoms Are Severe Or Do Not Go Away:

  • dizziness
  • weakness or heaviness in legs
  • lack of energy
  • cold, gray skin

Lisinopril and hydrochlorothiazide may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s MedWatch Adverse Event Reporting program online or by phone .

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Lisinopril For Type 2 Diabetes

by Med-World | Aug 18, 2015 | Learning Center I was recently diagnosed with type 2 Diabetes and put on several new medications because of it. One of the medications is Lisinopril. Upon doing my research, this seems to be a blood pressure pill, but I dont have high blood pressure. Could this be a mistake? Lisinopril is indeed primarily used as a blood pressure medication, but using it to treat diabetes is not a mistake. When a person develops diabetes they are at an increased risk of kidney problems, sometimes leading to chronic kidney disease. Lisinopril works specifically in the kidney by reducing constriction of the blood vessels surrounding it which helps benefit overall kidney function. These particular actions of Lisinopril are protective in nature. The ability of Lisinopril to protect the kidney reduces the risk of chronic kidney disease and slows the progression if there is existing chronic kidney disease. In fact, the American Diabetes Association says the addition of a blood pressure medication, such as Lisinopril, is the current recommended therapy for all patients who have been diagnosed with diabetes. With all that being said, your doctor is spot on! This weeks edition co-authored with Emma Siegmann, PharmD Candidate May 2016, SWOSU College of Pharmacy.Continue reading > >

How Does Lisinopril/hydrochlorothiazide Work

Protecting the Kidney in Diabetes

The combination drug lisinopril-hydrochlorothiazide lowers blood pressure through multiple mechanisms, including:

  • Lisinopril is acting as an ACE inhibitor. The medication blocks the production of the hormone angiotensin II, which causes blood vessels to constrict. By blocking production of that hormone, lisinopril causes blood vessels to relax, thus reducing blood pressure.
  • The hydrochlorothiazide part of lisinopril-hydrochlorothiazide lowers blood pressure by reducing the amount of sodium and water in the body. This reduces the volume of blood that the heart has to pump.
  • Hydochlorothiazide may also dilate blood vessels, which also helps lower blood pressure, but research into this is still ongoing.
  • Researchers are continuing to study the nuanced ways that ACE inhibitors and diuretics work independently and together to lower blood pressure.

    Your healthcare provider might recommend starting with just lisinopril or just hydrochlorothiazide in other cases, you might start with the combination pill.

    If you have questions about your course of treatment, be sure to ask your healthcare provider to explain why they chose a particular treatment. You deserve to understand your treatment options, so dont put off asking questions.

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    Can Lisinopril Oral Tablets Be Crushed Split Or Chewed

    It depends. In most cases, the tablets may be crushed, split, or chewed.

    But there are several manufacturers of lisinopril oral tablets. To make sure the lisinopril tablets youre prescribed can be crushed, split, or chewed, talk with your pharmacist or doctor first.

    If your tablets cant be crushed, split, or chewed, your doctor or pharmacist can recommend other treatments that may be easier for you to take. This may include other forms of lisinopril.

    Do not use more Lisinopril oral tablet than your doctor recommends. For some drugs, doing so may lead to unwanted side effects or overdose, such as hypotension .

    The Effects Of Lisinopril On Kidneys

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