Can Analgesics Hurt Kidneys
Check with your doctor to be sure you can use these medicines safely, particularly if you have kidney disease. Heavy or long-term use of some of these medicines, such as ibuprofen, naproxen, and higher dose aspirin, can cause chronic kidney disease known as chronic interstitial nephritis. The warning labels on over-the-counter analgesics tell you not to use these medicines for more than l0 days for pain and more than three days for fever. If you have pain and/or fever for a longer time, you should see your doctor. The doctor can check for possible medical problems and advise you about what medications you should take.
If you have decreased kidney function, painkillers called NSAIDs and higher dose aspirin are not recommended. Even with normal kidney function, you should use analgesics:
- Exactly as prescribed or as on the label
- At the lowest dose possible
- For the shortest period of time
What To Use Instead Of Ibuprofen
If youre hesitating about taking ibuprofen, you might be wondering what other medications in your medicine cabinet might be a better choice. Many people also keep some acetaminophen on hand, and for a lot of them, that might be a safe option.
Unlike ibuprofen, acetaminophen isnt an NSAID. Its an analgesic that combats pain, not inflammation, and some experts recommend choosing acetaminophen instead of NSAIDs if you have a condition like chronic kidney disease.
One 2019 study found the possibility of an increased risk of stroke among people with diabetes who took acetaminophen. The study examined data from more than 5,400 older adults living in nursing homes and ran six computerized models.
The researchers found that, overall, acetaminophen at therapeutic dosage levels seemed to be safe. But one of the six models found a significant increase in the risk of stroke among the residents with diabetes, and called for more research into acetaminophen use in older people with diabetes.
When in doubt about which med to use, talk with a medical professional.
Keeping Your Single Kidney Healthy
Treatment for childhood cancer sometimes requires the removal of one kidney. You can live a normal life with one kidney, as long as it remains healthy. Heres what you need to know to assess your risk for problems with your single kidney and to help keep it as healthy as possible.
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What Can I Do To Keep My Kidney Healthy
Follow these tips to help keep your kidney healthy:
- Drink plenty of water, especially when playing sports, while out in the sun, and during hot weather.
- Check with your doctor or pharmacist before taking any new prescription, over-the-counter, or herbal medicine. Make sure that they know that you have only one kidney.
- Use pain or fever medicine that contains aspirin, ibuprofen, acetaminophen, or naproxen with caution. These drugs, called non-steroidal anti-inflammatory drugs , can cause kidney damage, especially when taken in high doses or when two or more are taken with caffeine or codeine over long periods of time. If you need long-term medicine for pain, talk with your doctor about treatment options that wont harm your kidneys.
Nsaids And Acute Renal Failure
When possible, selective and nonselective NSAIDs should be avoided in patients with CKD, congestive heart failure, or liver cirrhosis to prevent ARF . There is some evidence to support increased incidence of adverse effects with increased dosing of selective and nonselective NSAIDs . Some medications, such as ACE inhibitors, angiotensin II-receptor blockers and -blockers, may increase NSAID-related renal complications.
NSAID treatment is a risk factor for contrast media induced nephropathy , mostly defined as a relative increase of serum creatinine by 25% or a decrease of GFR by 25% within 2472 hours after contrast media exposure. CIN is a common complication in high risk patients such as those with CKD and diabetes mellitus. Radiocontrast agents cause vasoconstriction of the vas afferens and may aggravate NSAID induced decrease in renal blood flow, GFR and intraglomerular pressure, particularly in risk patients treated with an ACE inhibitor or angiotensin II blocker. It is, therefore, recommended to discontinue selective or nonselective NSAID therapy 48 hours before administration of radiocontrast agents in those patients. Weisbord et al. , however, reported that 67 of 660 patients with GFR less than 60 mL/min/1.73 m² undergoing procedures with intravenous radiocontrast were prescribed NSAIDs but only three patients were instructed to discontinue the medication.
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Living With One Kidney 5 Things To Know
With many types of kidney cancer, surgical removal of the cancerous part of the kidney is part of treatment. This is also known as a nephrectomy. Depending on the size and location of your tumor, you may have had all or part of the kidney removed. People only need one kidney, but its very important to protect your remaining kidney function since the kidneys are responsible for filtering your blood and removing wastes from your body.
Nsaids And Blood Pressure
COX-2-inhibition enhances the pressure effect of angiotensin II . In patients with essential hypertension, even high doses of celecoxib did not cause any alteration of the antihypertensive effect of lisinopril . ACE inhibitors and angiotensin II receptor blockers are efferent renovasodilators and may cause functional, but reversible, renal insufficiency, which may worsen with NSAIDs by inducing afferent renovasoconstriction. Therefore, lowering of the dose of the NSAIDs as much as possible, lowering of salt intake, retitration of the antihypertensive and calcium channel blockers have been recommended when treating hypertension in a patient taking an NSAID. Another strategy is to use a non-NSAID, such as tramadol or aspirin . Interestingly, patients with rheumatoid arthritis or osteoarthritis and cardiorenal risk factors such as hypertension, congestive heart failure, edema, renal impairment, and advanced age were more likely to receive a coxib than other NSAIDs .
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Pain Reliever Linked To Kidney Injury In Endurance Runners
The common practice of taking ibuprofen for pain relief while competing in ultramarathons causes an increased risk of acute kidney injury, a Stanford study says.
Grant Lipman and his colleagues found that runners who took ibuprofen during ultramarathons doubled their risk for kidney injury.Paul Sakuma
People who take the painkiller ibuprofen while running very long distances double their risk of acute kidney injury, according to a study by researchers at the Stanford University School of Medicine and several other institutions.
As many as 75 percent of ultramarathoners use the nonsteroidal anti-inflammatory drug, or NSAID, in this fashion, according to Grant Lipman, MD, clinical associate professor of emergency medicine at Stanford and director of Stanford Wilderness Medicine. And while most cases of acute kidney injury appear to resolve spontaneously, the condition has the potential to progress to renal failure, he said.
Lipman is lead author of the study, which was published online July 5 in Emergency Medical Journal. Brian Krabak, MD, a sports and rehabilitation medicine specialist at the University of Washington-Seattle, is the senior author.
How To Cope With Side Effects
What to do about:
- headaches â make sure you rest and drink plenty of fluids. Dont drink too much alcohol. Talk to your doctor if they last longer than a week or are severe.
- feeling dizzy â if ibuprofen makes you feel dizzy, stop what youre doing and sit or lie down until you feel better. Avoid coffee, cigarettes and alcohol. If the dizziness doesnt get better within a couple of days, speak to your pharmacist or doctor.
- feeling sick â stick to simple meals. Do not eat rich or spicy food.
- being sick â have small, frequent sips of water. Speak to a pharmacist if you have signs of dehydration, such as peeing less than usual or having dark, strong-smelling pee. Dont take any other medicines to treat vomiting without speaking to a pharmacist or doctor.
- wind â try not to eat foods that cause wind . Eat smaller meals, eat and drink slowly, and exercise regularly. There are pharmacy medicines that can also help, such as charcoal tablets or simethicone.
- indigestion â if you get repeated indigestion stop taking ibuprofen and see your doctor as soon as possible. If you need something to ease the discomfort, try taking an antacid, but do not put off going to the doctor.
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Cox In Ureteral Obstruction And Lithium Nephropathy
The antidiuretic action of vasopressin depends on the exocytic insertion of AQP2 water channels from a store in intracellular vesicles to the apical plasma membrane of collecting duct principal cells, the so-called shuttle mechanism. Indomethacin markedly reduces the expression of AQP2 water channels in the collecting duct but enhances the shuttling of AQP2. The increased shuttling of APQ2 results in diminished urine volume. The altered urinary concentration ability and body water balance associated with the use of NSAIDs may in part be causally related with the alteration of AQP2 . Lithium treatment is one of the major causes of the acquired form of nephrogenic diabetes insipidus , a clinical syndrome in which the kidney is unable to concentrate urine despite normal or elevated concentrations of the antidiuretic hormone arginine vasopressin. In lithium-induced NDI rat models, downregulation of AQP2 has been demonstrated. For the treatment of NDI, NSAIDs or coxibs have been useful . The upregulation of AQP2 and the Na-K-2Cl inhibition underlies the therapeutic mechanisms by which COX-2 inhibitors enhance antidiuresis in patients with NDI .
Nsaids And Risk For Chronic Kidney Disease
Analgesic nephropathy is a slowly progressive chronic kidney disease resulting from daily use for many years of preparations containing at least two analgesics in combination with central-acting dependence-inducing substances, such as caffeine, codein, and/or barbiturates. Analgesic nephropathy is characterized by capillary sclerosis, renal cortical atrophy, chronic interstitial nephritis and/or papillary sclerosis/necrosis/calcifications. In a number of patients with analgesic nephropathy, the uroepithelia can develop transitional cell carcinoma. Analgesic nephropathy can be accurately diagnosed or excluded by computed tomography scanning without contrast media . Even if renal papillary necrosis occurs in patients with analgetic nephropathy, traditional NSAIDs including ibuprofen , tolmetin , indomethacin , benoxaprofen , and naproxen , have been also reported to cause renal papillary necrosis.
Gooch et al. determined the association between NSAID use and the progression of CKD in an elderly community-based cohort. A total of 10,184 subjects were followed for a median of 2.75 years. High-dose NSAID users was associated with an increased risk for rapid CKD progression among subjects with a baseline mean GFR between 60 and 89 mL/min/1.73 m² without risk differential between selective and nonselective NSAID users . Taken together, physicians should always prescribe the lowest effective dose of NSAIDs for the shortest possible time .
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Taking Ibuprofen Every Day Could Make Your Potassium Levels Skyrocket
When you take ibuprofen every day, you likely aren’t thinking about how it will impact your body’s potassium. However, perhaps you should give more thought to your potassium levels the next time you find yourself reaching for the Advil bottle.
Generally, people only think about potassium if they feel they don’t have enough of it. According to Healthline, muscle cramps, weakness, and fatigue are all signs of low potassium, which is probably why many people rely on bananas for their post-workout refreshment. However, if you take ibuprofen every day especially in high amounts you might end up accidentally skyrocketing your potassium levels. Unfortunately, this could present some dangers to your body.
According to GoodRx, non-steroidal anti-inflammatory drugs like ibuprofen “raise potassium levels by causing the kidneys to hold onto potassium.” And if your potassium is too high, your life could be at risk. As noted by GoodRx, potassium levels over 5.5 can cause a person to go into cardiac arrest, which could prove to be fatal. So, before you take a few Advil as a hangover cure, consider trying alternative remedies instead.
Nsaids Are Bad For Your Heart And Kidneys
Long-term use of NSAIDs can make your body hold onto fluid. This can make the symptoms of heart failure, such as shortness of breath, swollen ankles, and a rapid or irregular heartbeat, worse. NSAIDs can also keep the kidneys from working well. This makes taking NSAIDs risky for people who already have kidney disease.
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Check The Medications You Are Taking
If you have chronic kidney disease you should ask your doctor to check through the drugs you are taking. This is because some drugs pass out of the body by way of the kidneys, and the dose may need to be reduced if the kidneys are working less efficiently. Also, there are some drugs that are slightly toxic to the kidneys, and others that may cause problems with the levels of minerals in your blood.
Do tell your doctor if you take any tablets you buy at the chemist , of if you take any herbal or other alternative remedies, such as Echinacea, St John’s Wort or even vitamin supplements.
Medications to avoid taking if you have CKD belongs to a family of drugs called NSAIDs . There are several different drugs in this class, and they are painkillers used for arthritic pain or headaches. One type, ibuprofen, can be bought from the chemist or the supermarket without prescription check the label carefully if you are buying painkillers, as ibuprofen is sold under several different brand names . Many people with CKD have painful conditions and can take NSAIDs with careful supervision, but it is worth talking to your doctor about alternative painkillers. Paracetamol can be used safely if you have CKD, but remember to keep to the recommended doses.
How Is A Kidney Infection Treated
- Antibiotics treat your bacterial infection.
- Acetaminophen decreases pain and fever. It is available without a doctor’s order. Ask how much to take and how often to take it. Follow directions. Read the labels of all other medicines you are using to see if they also contain acetaminophen, or ask your doctor or pharmacist. Acetaminophen can cause liver damage if not taken correctly. Do not use more than 4 grams total of acetaminophen in one day.
- NSAIDs , such as ibuprofen, help decrease swelling, pain, and fever. This medicine is available with or without a doctor’s order. NSAIDs can cause stomach bleeding or kidney problems in certain people. If you take blood thinner medicine, always ask if NSAIDs are safe for you. Always read the medicine label and follow directions. Do not give these medicines to children under 6 months of age without direction from your child’s healthcare provider.
- Prescription pain medicine may be given. Ask how to take this medicine safely.
- Surgery may be needed if a ureter is blocked. The ureter is the tube that takes urine from a kidney to the bladder. A blocked ureter can cause repeated kidney infections.
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How Can I Manage My Symptoms
- Drink liquids as directed. You may need to drink extra liquids to help flush your kidneys and urinary system. Water is the best liquid to drink. Ask your healthcare provider how much liquid to drink each day and which liquids are best for you.
- Urinate as soon as you feel the urge. This will help flush bacteria from your urinary system. Do not wait or hold your urine for too long.
- Clean your genital area every day with soap and water. Wipe from front to back after you urinate or have a bowel movement. Wear cotton underwear. Fabrics such as nylon and polyester can stay damp. This can increase your risk for infection. Urinate within 15 minutes after you have sex.
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If You Taken Ibuprofen Every Day You Could Develop Internal Bleeding
Ibuprofen is a medicine cabinet staple for many families across the globe, as the over-the-counter painkiller is widely believed to be safe for people of all ages.
Whether you have a headache or a toothache, or you’re suffering from those pesky period cramps, ibuprofen is great for relieving pain. However, if you take too much of it every day, the NSAID can actually cause your body to bleed excessively.
Research from the Spanish Center for Pharmacoepidemiological Research in Madrid found that regular use of ibuprofen was fine however, when taken in excess every day, things could turn worrisome . According to the study, higher doses of ibuprofen could mean a “five-fold increased risk” of gastrointestinal bleeding or torn stomach lining. And as Alberta Health Services warns, if you already have gastrointestinal or rectal bleeding, taking ibuprofen or other NSAIDs to ease the pain might actually cause the bleeding to worsen.