The Relationship Between Ppis And Chronic Kidney Disease
One of the most recent studies comes from researchers at Johns Hopkins Bloomberg School of Public Health and published in JAMA Internal Medicine. The study, which involved over 250,000 people, found the use of PPIs was associated with a 20 to 50 percent higher risk of chronic kidney disease . While those behind the study are clear to point out that it doesnt directly prove that PPIs cause CKD due to the fact that the study was designed to determine correlation and not causation the results show a frightening risk for those taking these medications.
Researchers expressed concern about the frequency at which doctors prescribe these medicines, noting that PPIs are being prescribed for conditions like mild heartburn when the FDA recommends them only for more serious gastrointestinal disorders. One researcher pointed out that up to 90 percent of people taking PPIs dont exhibit indications or symptoms specified by the FDA. The takeaway is that not only do doctors need to be more cautious when prescribing or suggesting PPIs, but they should also be upfront with patients about the risks involved with taking these medications.
Nexium Prilosec Prevacid Lawsuit Consultation
If you or a loved one suffered a serious kidney injury or developed kidney disease after taking Nexium, Prilosec, or Prevacid, you may be eligible to receive financial compensation for your injuries.
If you have any questions at all, please contact our proton pump inhibitor lawyers for more information. There is no cost or obligation if you contact us we want to help you get the best legal representation available.
Prilosec Other Heartburn Meds Linked To Kidney Failure In The Elderly
Older patients taking proton pump inhibitors, a common remedy for heartburn and acid reflux, are two times more likely to be hospitalized with kidney failure than peers who don’t take the pills, a study finds.
While the side effect is extremely rare, and the study doesn’t prove the drugs cause kidney failure, the association is worrisome because tens of millions of people a year take these pills, sold by prescription and over-the-counter in some countries, with brand names including Prilosec, Prevacid and Zegerid.
“Generally, the drugs are very well tolerated, and the vast majority of patients who take them will not develop or other serious problems,” lead study author Tony Antoniou, a researcher at the Institute for Clinical Evaluative Sciences and St. Michael’s Hospital in Toronto, said by email. “But the drugs should be used for the shortest possible duration.”
Antoniou and colleagues identified about 290,000 people aged 66 or older taking proton pump inhibitors in Ontario between 2002 and 2011, as well as a similar number of individuals not taking the drugs.
The researchers then looked at how many people were hospitalized for acute kidney injury within 120 days of starting treatment, and compared that to the group not taking the drugs.
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What Are Proton Pump Inhibitors
Proton pump inhibitors are medications that help to ease the symptoms of acid reflux. These medications work by blocking enzyme-producing acids and reducing the production of acid in the stomach. These drugs are available in both prescription and over the counter form. Omeprazole is sometimes used in combination with antibiotics to treat ulcers linked to an infection by the H. Pylori bacteria.
When the stomach over-produces acids, ulcers and sores may form in the esophagus, stomach, and duodenum. These problems can present themselves in the form of symptoms like heartburn, persistent coughing, and difficulty swallowing. Patients who reduce their stomach acid through the use of PPIs like Prilosecallow these sores time to heal. Other common PPI drugs are Nexium and Prevacid .
In the United States, PPI drugs are some of the most commonly used medications. In fact, about 21 million Americans were prescribed PPI drugs in 2009. Now, about 10 percent of American adults take some kind of PPI medication.
Ppis And Acute Interstitial Nephritis
Weve all been taught this and have likely passed this association on to trainees over the years. Although AIN is not a common phenomenon, the high prevalence of the use of PPI medications brings this association closer to the surface. Because of how often these medicines are used, the exact incidence is tough to pin down, but some studies suggest that this class may be the leading cause of drug-induced AIN. In a single-center UK study of 24 biopsy-confirmed cases of tubulointerstitial nephritis, 14 cases were thought to be drug-induced, and 8 of 14 were presumed to be related to omeprazole or lansoprazole. Other studies have consistently reproduced this association as well. For the small subset of patients that experience AIN from this class of medications, it should be listed as a true allergy and they should not be re-challenged. If continued acid suppression therapy is needed, H2 blockers can be considered. Heres a case I had from a few years back in a patient we biopsied for AKI who was taking a PPI:
Biopsy slide showing a case of acute interstitial nephritis associated with proton pump inhibitor use.
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Database Design And Processing
After all data were collected, a database was constructed and filled using Epidata software version 3.1. Data were double typed. The Kappa agreement test was applied to validate the database, resulting in a Kappa coefficient of 0.92, reflecting an almost perfect agreement . Data were exported to the Statistical Package for the Social Sciences version 20 for statistical analysis. The STATA SE version 12.0 software was used for Cox regression analysis.
If You Have Kidney Disease Other Medications Can Be Harmful
If your kidneys are already damaged, certain drugs can make them worse or lead to kidney failure. Talk to your doctor before taking cholesterol or diabetes medication, antacid medicine for an upset stomach, or antimicrobial meds, like antifungal and antiviral drugs. In some cases, you may be able to take a smaller dose thats safer for you.
You also should talk to your doctor before having some kinds of imaging tests. With a magnetic resonance imaging or computed tomography scan, doctors sometimes use a dye to help them see a specific area of your body better. In rare cases, this dye can cause serious conditions called contrast-induced nephropathy or nephrogenic systemic fibrosis . Ask your doctor about other tests you might have instead.
National Kidney Foundation: Contrast Dye and the Kidneys,How Your Kidneys Work,Oral Sodium Phosphate Safety Alerts,Pain Medicines ,Watch out for Your Kidneys When You Use Medicines for Pain,Which Drugs are Harmful to Your Kidneys?
MedShadow: 6 Medications That Can Harm the Kidneys.
Cleveland Clinic: Supplements, OTCs May Hurt Your Kidneys.
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What Is Chronic Kidney Disease
Chronic kidney disease, also called chronic kidney failure, is a progressive loss of kidney function. When chronic kidney disease progresses significantly, dangerous wastes and fluids can build up in a sufferers body.
Kidney failure is a silent disease. In the early stages of chronic kidney failure, individuals may not notice any symptoms. The disease typically does not manifest with signs and symptoms until it is at an advanced stage.
Unfortunately, there is to date no cure for chronic kidney disease. Patients typically progress to kidney failure and will eventually require dialysis or a kidney transplant to stay alive.
How Does Prilosec Work
Prilosec works in the same way as other proton pump inhibitors, by blocking the production of stomach acid. It does this by blocking the enzyme H+/K+ATPase on the stomachs parietal cells. This enzyme is involved in the final stage of the production of stomach acid. By inhibiting that final step, Prilosec and other PPIs block the production of stomach acid.
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What Is The Link Between Ppis And Kidney Failure
In some cases, the kidney damage caused by PPIs can be very serious. In 2019, researchers at the University at Buffalo School of Pharmacy and Pharmaceutical Sciences published a study which found that PPI users were 20% more likely to develop chronic kidney disease and four times more likely to develop acute kidney injury than non-users.
If left untreated, these problems can lead to kidney failure in some patients. Kidney failure occurs when the kidneys can no longer effectively remove waste products from the body. Patients who develop kidney failure may need dialysis or a kidney transplant in order to keep them alive.
Even more troubling is the fact that many of these patients show no signs of kidney problems before the onset of renal failure. According to a 2017 study by scientists at the Washington University School of Medicine, the kidney problems caused by PPIs can develop silently and gradually over time, eroding kidney function and leading to long-term kidney damage or even renal failure. The study found that more than 50% of PPI users who developed kidney failure or chronic kidney disease showed no symptoms before they were diagnosed.
Study Design And Population
This is a retrospective cohort study developed at the nephrology ambulatory sector of the Municipal Polyclinic of Divinópolis-MG, Brazil, from March 2017 to March 2019, following the STROBE checklist for observational research. Eligibility criteria were defined as all adult and elderly patients of both genders with established CKD diagnosis who were already undergoing clinical follow-up or who were diagnosed after insertion in the nephrology ambulatory clinic in the years 2016 and 2017. During this period, 241 patients were attended. Of these, 42 patients were excluded due to lack of confirmation of CKD diagnosis , absent creatinine values and history of neoplasms . Patients without baseline creatinine values were excluded from the study because it would not be possible to determine the estimated glomerular filtration rate and thus the baseline CKD stage. Similarly, those patients who had not recorded serum creatinine values at subsequent times were also excluded. Patients who underwent previous kidney transplantation and/or patients on renal replacement therapy, and patients who had missing data related to some of the variables used during the two-year follow-up were not included in this study. Thus, a total of 199 patients with CKD eligible for the study were included.
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Warnings For People With Certain Health Conditions
For people with moderate or severe kidney disease: If you have kidney problems, you may not be able to clear this drug from your body. This may increase the levels of this drug in your body. The increased levels may cause more side effects, such as confusion and an irregular heart rhythm called QT prolongation.
Large Study Connects Proton Pump Inhibitors With Risks For Ckd Aki
Hart E, et al. Pharmacotherapy. 2019 doi:https://doi.org/10.1002/phar.2235.
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A study that examined the use of common heartburn medications in a large patient population showed ties between the medications and CKD and acute kidney failure later in life.
University at Buffalo researchers reviewed the medical records of 190,000 patients older than 15 years of age and found acid reflux drugs increased the risk of kidney disease by 20% and the risk of kidney failure by four times compared to individuals unexposed to the drugs. Risks were highest among people at least 65 years old, the researchers said.
Although PPIs are one of the most commonly prescribed medications, 25% to 70%
The researchers looked at the medical history of adult patients with no evidence of pre-existing renal disease and who were started on PPI therapy and continuously enrolled in a Western New York HMO for at least 12 months between July 1993 and September 2008. Kidney health was compared between patients who underwent PPI therapy and a control group. Examined PPIs included esomeprazole , lansoprazole , omeprazole , pantoprazole and rabeprazole .
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Famotidine May Interact With Other Medications
Famotidine oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.
To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs youre taking. To find out how this drug might interact with something else youre taking, talk to your doctor or pharmacist.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Famotidine oral tablet comes with several warnings.
What Are The Side Effects Of Ppis
Although they are among the most widely prescribed medications in the U.S., researchers have linked PPIs to an increased risk of serious and potentially deadly side effects.
One of the most dangerous side effects linked to the use of PPI medications is kidney disease. Studies have shown that long-term PPI users are more likely than patients taking H2 blockers to develop problems with their kidneys, including kidney damage and kidney failure.
Other side effects that have been linked to the use of PPIs include an increased risk of fractures, increased pneumonia risk, an increased risk of Clostridium difficile infections, iron and Vitamin B12 deficiency, and interactions with some other prescription drugs.
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Omeprazole May Worsen The Progression Of Chronic Kidney Disease
The use of PPIs, in particular omeprazole, has also been associated with the development of CKD. It is thought that this may be due to omeprazole causing oxidative stress and renal tubular cell death.
In one study following 199 patients with CKD for a year, 70.6 percent of patients using omeprazole had disease progression compared with only 10.5 percent of patients who did not take omeprazole.
An analysis of Food and Drug Administration post marketing surveillance data has also shown that people taking PPIs are 28.4 times more likely to report CKD and 35.5 times more likely to report end-stage renal disease than people taking histamine-2 receptor antagonists . H2RAs, or H2 blockers, are another class of drug used to reduce the amount of acid produced in the stomach, but they are not considered to work as well as PPIs. Examples of H2 blockers include nizatidine , famotidine and cimetidine .
Any Validity To Ppis And Kidney Stones
A study published in the journal Nutrients discussed a link between PPIs and kidney stones.
The authors note:
Within the PPI cohort, patients who received the following PPIs as monotherapy had a significant increase in the frequency of nephrolithiasis reports: omeprazole , esomeprazole , pantoprazole , and lansoprazole .
That means people taking omeprazole, lansoprazole or pantoprazole were at least three times more likely than those not on such drugs to report kidney stones. Read more about PPIs and kidney damage at this link:
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Do I Qualify To File A Lawsuit
If you or a loved one used PPIs like Prevacid, Prilosec, Protonix, or Nexium and were diagnosed with kidney failure or kidney disease, you may qualify to take legal action. The first step in filing a PPI lawsuit is to speak with an experienced pharmaceutical liability attorney, who can advise you regarding your legal rights.
For more information about filing a PPI claim and to find out whether you may be eligible to take legal action, contact the law firm of Hissey Mulderig & Friend for a free legal consultation. You can reach us by calling our attorneys toll-free at , or by filling out the free case evaluation form on the right side of this page.
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Should I Consider Hiring A Prilosec Lawyer
If you or a loved one has taken Prilosec long-term, you may have a case against AstraZeneca. Theres no guarantee for any case, so each must be weighed on its own merits. Seeger Weiss offers a free consultation in order to evaluate each case. If you or your loved one has suffered from medical complications due to taking Prilosec, you may be eligible for compensation if your case is successful. This compensation could be awarded for the following:
- Wrongful death
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Prilosec Class Action Lawsuit
The Phillips Law Group does not accept cases involving the generic version of Prilosec, marketed as Omeprazole.
The Phillips Law Groups defective drug attorneys are currently reviewing cases on behalf of individuals who took Prilosec or Nexium and suffered chronic kidney disease or other serious side effects.
If you or a loved one suffered from acute interstitial nephritis, chronic kidney disease, renal/kidney failure or acute kidney injury after using the name-brand drug Prilosec, you may be entitled to file a Prilosec lawsuit. Do not hesitate to contact our dedicated defective drug attorneys for a free, no obligation consultation. Throughout our more than 20 years as one of Arizonas largest consumer advocacy law firms, we have been strong advocates of consumers right to safe and reliable products. We will not hesitate to pursue legal action against negligent corporations and hold them liable for the pain and suffering they caused.
We have successfully obtained millions in verdicts and settlements for our clients and continue to fight for the maximum compensation for each claim we represent. All of our services are provided on a contingency fee basis, which means we do not get paid unless we secure a favorable verdict or settlement for your case.
For more information about joining a Prilosec lawsuit, call or text .