Naproxen May Damage Kidneys
One of the most popular NSAIDs in the pharmacy is naproxen. It was originally only available by prescription under the name Naprosyn. Now doctors can write prescriptions for naproxen as a generic pain reliever or under the brand names Anaprox, Anaprox DS, EC-Naprosyn, Naprelan and Vimovo .
Naproxen has also been available over the counter for years in products like Aleve, Aleve PM, Menstridol or Midol Extended Relief. There are also dozens of house brand naproxen products people can buy without medical supervision.
We fear that this NSAID as well as similar drugs have a long list of serious side effects that most people are either unaware of or ignore. Kidney damage is just one complication to pay attention to as this reader notes.
Why Is Advil Bad For Your Kidneys If It Is Processed By The Liver And Tylenol Not So Harmful When I
- 10 Jan 2014 by Twfinklea
Advil, Excedrin, and Motrin have Ibuprofen in them. Aspirin and Ibuprofen are not good for people with kidney disease. I have Chronic Kidney Disease Stage 3, and aspirin caused me to go into Acute Renal Failure. My Nephrologist told me, NO aspirin, NO ibuprofen. Advil and Excedrin were the only thing that helped me with headaches or arthritis pain and it has been very hard for me to stick to Tylenol. You can be sure if you take too much Tylenol, it can also cause issues with the kidneys, so I take 1/2 the dose of 500 mg. Drinking lots of water has helped more than anything. Most people don’t take medication with a full glass of water. Just a sip will do they think. But to protect your body parts, use lots of water.Hope this helps.
Taking Nsaid Pain Relievers For Granted:
If you come down with a headache or your back starts to hurt, the go-to drugs of choice are nonsteroidal anti-inflammatory drugs . Millions of people rely on pain relievers like celecoxib , diclofenac , ibuprofen , meloxicam and naproxen to get through the day.
We have heard from many people in pain that they cant manage without an NSAID. Here are just a couple of comments from readers:
Angela in Portland, Oregon relies on ibuprofen:
Advil is my go-to pain reliever. I only use it when its all that will work for me. I have tried through the years to find another pain reliever. If my pain is manageable I dont take anything. I only take it when I dont have a choice. I dont know what I would do without Advil.
Michelle in Marietta, Georgia, also depends on ibuprofen:
Ive been using 800 Motrin for as long as its been available. I remember seeing a Mayo Clinic TV Special and they used it as a first try against pain. It was their go to pain reliever. It ALWAYS helps my pain. After two shoulder surgeries I took two hydrocodone pills, then only 800 Motrin. The doctor couldnt believe I wasnt taking the hydrocodone. Same with my knee replacement.
Vaudi in Fayetteville, North Carolina, loves Celebrex:
Ive taken Celebrex for years. When I had back surgery a year ago, I had to stop Celebrex for 3 months. I could barely move. I couldnt wait till the day when my spinal neurosurgeon said I could take Celebrex again. At last I had a spring in my step and felt great.
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Other Stories About Nsaid Pain Relievers:
Bob in Chapel Hill, NC, on NSAIDs and Kidney Damage
I had to stop regular use of naproxen because of kidney damage. I was an orthopedic surgeon for 40 years. I had to stop prescribing the NSAID butazolidin because it caused leukemia and a number of other side effects. Then I became more cautious about prescribing other NSAIDs because of the risk of heart attacks,
HW on ibuprofen:
I have had several experiences with side effects of a severe nature. A friend took Motrin for arthritis. It led to kidney failure. That led to a kidney transplant. My friend subsequently died from complications.
My husband took aspirin, then Motrin and other NSAIDS for arthritis. He developed a severe allergy that caused serum sickness. Just because these drugs are available over the counter does not mean they are harmless.
What Are The Complications Of Analgesic Nephropathy
Some cases of acute kidney failure have been linked to the use of painkillers, including aspirin, ibuprofen, and naproxen. Many of these people had risk factors, such as:
- Chronic kidney conditions
- Recent binge-drinking alcohol
Talk with your healthcare provider for more information about diagnosis and treatment of analgesic nephropathy and kidney failure.
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What Are The Symptoms Of Analgesic Nephropathy
These are the most common symptoms of analgesic nephropathy:
- Fatigue or weakness, feeling unwell
- Blood in the urine
- An increase in urination frequency or urgency
- Pain in the back or flank area
- A decrease in urine output
- Nausea, vomiting
- Widespread swelling
- Easy bruising or bleeding
Some people have no symptoms. Kidney damage may be picked up by routine blood tests. The symptoms of analgesic nephropathy may look like other medical conditions or problems. Always talk with your healthcare provider for a diagnosis.
How Does Ibuprofen Or Acetaminophen Affect To Kidney
NSAIDs have important unfavorable effects on the kidney that you should know about.
Here is the science behind the issue. Ibuprofen and other NSAIDs hinder prostaglandins, and that can cause an issue due to the fact that prostaglandins dilate capillary resulting in the kidneys, according to iytmed.com. Preventing prostaglandins may result in kidney anemia and therefore severe kidney injury.
A simple blood test might show a rise in creatinine if your kidneys are being affected, typically seen within the first 3 to seven days of NSAID therapy. Severe kidney injury can occur with any NSAID though naproxen appears to be a bigger culprit. In one study, folks who took NSAIDs had twice the risk of acute kidney injury within 30 days of starting to take the NSAIDs. Good news is its reversible if you stop taking them.
In individuals with hypertension, taking NSAIDs long term may aggravate underlying hypertension. Individuals with kidney problems at baseline regularly get in difficulty with NSAIDs, however if you are taking ibuprofen for extended periods of time its not a bad idea to have a check of your kidney function with a quick blood test. Keep in mind, intense kidney injury from NSAIDs does not cause any symptoms.
NSAIDs are safe for the liver, but can cause a problem with kidney function that is reversible if you stop taking them. Typically safe but worth taking notice of.
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Is Aspirin Safe For Regular Use
When taken as directed, regular use of aspirin does not seem to increase the risk of kidney disease in people who have normal kidney function. However, taking doses that are too large may temporarily- and possibly permanently- reduce kidney function. In people with kidney disease, aspirin may increase the tendency to bleed. People who already have reduced kidney function, or other health problems such as liver disease or severe heart failure, should not use aspirin without speaking to their doctor.
Early Detection Is Critical
People with declining kidney function typically experience no symptoms until failure is imminent. And until recently doctors had no good way to detect early signs of kidney failure. The most accurate measure required 24-hour urine collection. Simpler tests were so insensitive that by the time they showed abnormalities, the kidneys had often already lost more than half their filtering capacity.But now researchers have validated a faster, easier way to detect kidney trouble: a blood test that is factored into a formula that also uses age, gender, and race to estimate the kidney’s filtration rate, combined with a test to measure excreted protein. Testing is especially important if you’re age 60 or over have a personal history of diabetes, heart disease, high blood pressure, or any kidney disease or have a family history of kidney disease.An abnormal result, especially on the protein test, does not necessarily mean that you have kidney damage, since a bladder infection or other problems can increase protein excretion. If you have an abnormal result, get retested in a few months. A second abnormal finding indicates the need for further investigation.
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How To Read Your Urine
Fortunately, no one still practices the medieval art of assessing health by tasting the urine. But changes in your urine or your urinary habits can provide warning signs of danger from disease or certain drugsor they may be harmless changes caused by food, supplements, or certain other drugs. This table can help you make that distinction. In general, consult your physician promptly about a urinary change if you have not consumed any of the benign substances listed below, or if you have any of the potentially harmful conditions or are taking any of the drugs listed. All but one of the potentially harmful medications affect the urine by impairing kidney function the exception is warfarin, which can redden the urine by causing bleeding.You may not have to contact your doctor quickly in two cases: You can usually treat dehydration simply by drinking more fluids if there are no other symptoms and you can usually wait a day or two before calling your doctor about a suspected urinary-tract infection, unless you have severe symptoms, such as back pain or fever.
|Urinary signs or symptoms|
Regular Use Of Pain Medicines Doesn’t Damage Kidneys
July 17, 2001 — Aspirin and similar pain medicines are such a part of everyday life — about a quarter of U.S. adults use them weekly — that most of us assume they’re perfectly safe. But for years, doctors have cautioned that regular use of these drugs can cause major damage to your kidneys and cause bleeding in the stomach.
A new study gives us one less thing to worry about: Moderate use of over-the-counter pain relievers isn’t likely to lead to kidney problems, the researchers found. However, two doctors who reviewed the study for WebMD believe overuse of pain medicines, particularly over a long period of time, may still be harmful.
The study in July 18 issue of the Journal of the American Medical Association looked at the use of nonprescription pain medicines such as aspirin, acetaminophen and non-steroidal anti-inflammatory drugs such as Motrin, Advil, or Aleve in more than 11,000 healthy men over a 14-year period.
They found no increase in kidney problems among men who took an average of three or four pills a week The study didn’t look at other possible side effects of these drugs such as harm to the liver or gastrointestinal bleeding.
People in the U.S. tend to drink too little water, and that puts additional stress on the kidneys, Avram says. “When you look at elderly people who drink only a small amount of water, and also take lots of pain medicines, that’s a set-up for disaster.”
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Could Diclofenac Gel Harm Your Kidneys
Q. I am especially sensitive to NSAIDs because of impaired kidney function. My doctor prescribed diclofenac gel for a muscle injury. Am I absorbing enough of this product to be harmful?
A. Nonsteroidal anti-inflammatory drugs like diclofenac, ibuprofen or naproxen can be hard on the kidneys. The official prescribing information for diclofenac warns that long-term administration could cause renal injury.
It is not clear whether you would absorb enough diclofenac from a topical gel to harm your kidneys. This is best determined by frequent monitoring. Ask your doctor to check your kidney function carefully.
Nsaids Are Bad For Your Blood Pressure
NSAIDs can cause high blood pressure. And if you have high blood pressure, they can make it worse. This increases your chances of having a heart attack or a stroke.
NSAIDs can also keep some blood pressure drugs from working right. NSAIDs can interfere with:
- Diuretics, or water pills, such as Hydrodiuril . Diuretics remove excess water from the blood vessels.
- ACE inhibitors, such as Prinivil and Zestril . ACE inhibitors are drugs that relax the blood vessels.
- ARBs such as Cozaar . ARBs are another group of drugs that relax the blood vessels.
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Plan Ahead To Manage Pain Flu Or Other Illness
Almost everyone gets sick once in a while. Your doctor or pharmacist can help you plan ahead to keep your kidneys safe until you get well. Prepare in advance so you know what to do if you have pain or a fever, diarrhea, nausea, or vomiting, which can lead to dehydration.
Before you get sick, ask your health care provider or pharmacist the following questions
- If I get sick, are there medicines I should not take while Im sick?
- If I need to stop medicines when Im sick, when can I restart them?
- What can I take or do to relieve a headache or other pain?
- What can I take to relieve a fever?
- If I have diarrhea or am vomiting, do I need to change how or when I take my blood pressure medicine?
Heart Attacks Strokes And Heart Failure:
There is growing recognition that NSAIDs can affect the cardiovascular system. Although most people do not understand heart failure very well , the outcomes can be disastrous. NSAIDs increase the risk of heart failure and if people have this condition NSAIDs can make it substantially worse .
An ongoing controversy in the medical community is whether some NSAIDs are more or less likely to cause heart attacks or strokes. Some studies suggest that naproxen may be a little less of a problem than some of the other pain relievers in this class. That said, the FDA has not given naproxen a green light in this matter. A study published in Current Vascular Pharmacology suggested the following:
The best safety profile related to MI was found for naproxen, while the worst safety profile, with excessively increased risk for stroke, MI and major bleeding, was for diclofenac. Naproxen showed higher risk for major bleeding than ibuprofen and the risk for stroke was slightly higher than ibuprofen. Regarding heart failure, ibuprofen presented the highest risk while the highest risk for AF was attributed to current use of diclofenac.
Here are some stories from readers to bring all this into focus. You can read more in the comment section below this article.
Rick was quite athletic and healthy until this happened:
Nana from Houston shared this:
Sherry in Waxhaw, NC points out that it took the FDA a long time to discover that NSAIDs could cause heart problems:
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Symptoms Of Kidney Disease
Kidney disease is called a silent disease as there are often no warning signs. People may lose up to 90 per cent of their kidney function before getting any symptoms. The first signs of kidney disease may be general and can include:
- high blood pressure
- changes in the amount and number of times urine is passed
- changes in the appearance of urine
- blood in the urine
- puffiness of the legs and ankles
- pain in the kidney area
- have a family history of kidney failure
- have a history of acute kidney injury
- are of Aboriginal or Torres Strait Islander origin.
Can Analgesics Hurt Kidneys
Check with your doctor to be sure you can use these medicines safely, particularly if you have kidney disease. Heavy or long-term use of some of these medicines, such as ibuprofen, naproxen, and higher dose aspirin, can cause chronic kidney disease known as chronic interstitial nephritis. The warning labels on over-the-counter analgesics tell you not to use these medicines for more than l0 days for pain and more than three days for fever. If you have pain and/or fever for a longer time, you should see your doctor. The doctor can check for possible medical problems and advise you about what medications you should take.
If you have decreased kidney function, painkillers called NSAIDs and higher dose aspirin are not recommended. Even with normal kidney function, you should use analgesics:
- Exactly as prescribed or as on the label
- At the lowest dose possible
- For the shortest period of time
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