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Does Naproxen Affect The Kidneys

How Should This Medicine Be Used

What Ibuprofen Does to the Body

Prescription naproxen comes as a regular tablet, a delayed-release tablet, an extended-release tablet, and a suspension to take by mouth. The extended-release tablets are usually taken once a day. The tablets, delayed-release tablets, and suspension are usually taken twice a day for arthritis. The tablets and suspension are usually taken every 8 hours for gout, and every 6 to 8 hours as needed for pain. If you are taking naproxen on a regular basis, you should take it at the same time every day.

Nonprescription naproxen comes as tablet and a gelatin coated tablet to take by mouth. It is usually taken with a full glass of water every 8 to 12 hours as needed. Nonprescription naproxen may be taken with food or milk to prevent nausea.

Follow the directions on the package or prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take naproxen exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor or written on the package.

Shake the liquid well before each use to mix the medication evenly. Use the measuring cup provided to measure each dose of the liquid.

Swallow the delayed-release tablets and extended release tablets whole do not split, chew, or crush them.

If you are taking naproxen to relieve the symptoms of arthritis, your symptoms may begin to improve within 1 week. It may take 2 weeks or longer for you to feel the full benefit of the medication.

Side Effects From Long

Long-term use of Aleve can make your heart work harder. Aleve makes you retain water, which increases the load on your heart. This extra work can cause pressure on your cardiovascular system and can sometimes lead to a heart attack or stroke. These risks are even greater at higher dosages, even if you dont have any heart conditions or risk of heart disease. Call 911 or local emergency services if you have:

  • chest pain
  • slurred speech
  • weakness in your arms or legs

These are signs of a stroke or heart attack. If you take Aleve and have unexplained weight gain or swelling, especially in your legs and feet, talk to your doctor right away. These may be signs of heart failure. To lower your risk of heart problems, use the lowest dosage for the shortest amount of time.

Prostaglandins maintain the pressure in your kidneys so that these organs can filter the fluids in your body. A decrease in your level of prostaglandins from taking Aleve can cause problems with your kidney function. You may notice fluid retention or changes in how much you urinate. If you notice these changes while taking Aleve, stop taking it and contact your doctor.

People with certain medical conditions may experience more side effects from Aleve than other people. These conditions include:

What Are The Complications Of Analgesic Nephropathy

Some cases of acute kidney failure have been linked to the use of painkillers, including aspirin, ibuprofen, and naproxen. Many of these people had risk factors, such as:

  • Lupus
  • Chronic kidney conditions
  • Recent binge-drinking alcohol

Talk with your healthcare provider for more information about diagnosis and treatment of analgesic nephropathy and kidney failure.

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Dosage For Osteoarthritis Rheumatoid Arthritis And Ankylosing Spondylitis

Adult dosage


Immediate-release oral tablet

  • The typical dosage is 500 to 1,000 mg daily in two divided doses.
  • The maximum dose is 1,500 mg per day. This should be given for a limited time period .

Delayed-release oral tablet

  • The typical dosage 375 to 500 mg twice daily.
  • The maximum dose is 1,500 mg per day. This should be given for a limited time period .

Naproxen sodium:

Immediate-release oral tablet

  • The typical dosage is 275 to 550 mg twice daily.
  • The maximum dose is 1,650 mg per day. This should be given for a limited time period .

Extended-release oral tablet

  • The typical dosage is 750 or 1,000 mg once daily.
  • The maximum dose is 1,500 mg per day. This should be given for a limited time period.

Child dosage

A dosage for people younger than 18 years hasnt been established.

Special dosage considerations

If youre older than 65 years, your body may process this drug more slowly. Your doctor may start you on a lowered dose so that too much of this drug doesnt build up in your body. Too much of the drug in your body can be dangerous.

Place In Therapy For Nsaids In Patients With Ckd

Is acetaminophen hard on kidneys with MasterCard

Rather than widespread NSAID avoidance in kidney disease, we advocate a patient-centered approach to NSAID use. Key considerations for use should include indication for therapy , expected dose and duration, individual risk profile, suitability of alternative options, and goals of care.

Pain is classified as nociceptive or as neuropathic . Knowing which type of pain a patient has helps to both generate a differential diagnosis and guide management. The Centers for Disease Control and Prevention published guidelines in 2016 that recommend nonpharmacologic interventions as first line in all patients for the management of chronic pain regardless of type . Nonpharmacologic interventions such as physical therapy, acupuncture, behavior management techniques, mindfulness, and music therapy are evidenced-based for the management of chronic pain . When nonpharmacologic interventions are not possible or not effective, pharmacologic modalities are entertained. The World Health Organization developed a pain ladder for the pharmacologic management of pain, which has been suggested for use in CKD and validated in ESKD . The first step of the WHO pain ladder includes nonopioid medications such as acetaminophen, and topical or oral NSAIDs, Step 1 also can include adjuvant medications that predominately target neuropathic pain such as tricyclic antidepressants, serotonin-NE reuptake inhibitors, gabapentinoids. Steps 2 and 3 of the WHO pain ladder include the use of opioid pain relievers.

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What Are Clinical Trials And Are They Right For You

Clinical trials are part of clinical research and at the heart of all medical advances. Clinical trials look at new ways to prevent, detect, or treat disease. Researchers also use clinical trials to look at other aspects of care, such as improving the quality of life for people with chronic illnesses. Find out if clinical trials are right for you.

Plan Ahead To Manage Pain Flu Or Other Illness

Almost everyone gets sick once in a while. Your doctor or pharmacist can help you plan ahead to keep your kidneys safe until you get well. Prepare in advance so you know what to do if you have pain or a fever, diarrhea, nausea, or vomiting, which can lead to dehydration.

Before you get sick, ask your health care provider or pharmacist the following questions

  • If I get sick, are there medicines I should not take while Im sick?
  • If I need to stop medicines when Im sick, when can I restart them?
  • What can I take or do to relieve a headache or other pain?
  • What can I take to relieve a fever?
  • If I have diarrhea or am vomiting, do I need to change how or when I take my blood pressure medicine?

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What Clinical Trials Are Open

Clinical trials that are currently open and are recruiting can be viewed at

This content is provided as a service of the National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health. The NIDDK translates and disseminates research findings to increase knowledge and understanding about health and disease among patients, health professionals, and the public. Content produced by the NIDDK is carefully reviewed by NIDDK scientists and other experts.

The NIDDK would like to thank Jeffrey Fink, MD, MS, Chief, Division of General Internal Medicine, University of Maryland School of Medicine

Do Nsaids Cause Kidney Injury

Keeping Kidneys Safe – Know How Medicines Affect the Kidneys

Non-steroidal anti-inflammatory drugs, or NSAIDs, are medications that help to reduce inflammation. They also control pain and fever and are available over the counter and by prescription. Common NSAIDs include ibuprofen , aspirin , and naproxen sodium . These drugs are typically safe if they are used infrequently, but for people with decreased kidney function or chronic kidney disease, they should be avoided.

Are NSAIDs safe to take?NSAIDs are typically safe to use. However, many patients are sensitive to the side effects of these medications, even with normal kidney function. If you have reduced kidney function or have a number of other medical conditions, you may be much more likely to have problems with taking these drugs.

NSAIDs can affect kidneys by several different mechanisms. They can cause high blood pressure and can also interact with some blood pressure drugs in a way that prevents them from working correctly such as diuretics, ACE inhibitors, and ARBs which are a group of drugs that are designed to relax blood vessels. NSAIDs may increase your fluid retention and can lead to decreased blood flow to kidneys. This is because NSAIDs block prostaglandins, which are the natural chemicals that dilate blood vessels and allow oxygen to reach the kidneys to keep them alive and healthy.

As the regional expert in the diagnosis and treatment of kidney disease, Ochsner offers a full range of nephrology services. Learn more here.

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How Do I Know If Analgesics Have Affected My Kidneys

Your doctor can check your kidneys by doing a simple blood test called a serum creatinine level. This test measures the amount of a waste product in your blood that is normally removed by your kidneys. If your kidneys are not working as well as they should, the creatinine level will be increased in your blood. The results of the serum creatinine test can be used to estimate your glomerular filtration rate . Your GFR number tells your doctor how much kidney function you have.

A urine test for the presence of protein may also be done. Persistent protein in the urine may be an early indication of kidney damage.

What Analgesics Are Safe For People Who Have Kidney Disease

Acetaminophen remains the drug of choice for occasional use in patients with kidney disease because of bleeding complications that may occur when these patients use aspirin. However, kidney patients who need to use acetaminophen habitually should be supervised by their doctors and be sure to avoid drinking alcohol while on this medicine.

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Flu Vaccines For People With Ckd

  • Injectable influenza vaccines are recommended for use in people with CKD and other health conditions. The flu shot has a long, established safety record in people with CKD.
  • The live attenuated influenza vaccine , also known as the nasal spray vaccine, is not recommended for people with some kinds of chronic health conditions because the safety and effectiveness of this vaccine in people with those conditions has not been established. The nasal spray vaccineis not recommended for people with CKD.

Your doctor or other health care professional can answer any questions you might have about flu vaccine.

Get pneumococcal vaccines.

  • Pneumococcal pneumonia is an example of a serious flu-related complication that can cause death.
  • People who have CKD should also be up to date with pneumococcal vaccination to protect against pneumococcal disease, such as pneumonia, meningitis, and bloodstream infections.
  • You can get either Pneumococcal conjugate vaccine or Pneumococcal polysaccharide vaccine when you get the flu vaccine.
  • Talk to your doctor to find out which pneumococcal vaccines are recommended for you.

Talk with your doctor about other vaccines, including the hepatitis B vaccine, you may need if you have CKD.

Physiology And Pathophysiology Of Cox Inhibition

The Effects of Ibuprofen on the Liver &  Kidneys

PGs regulate a wide variety of renal functions . PGE2 is considered to be mainly a tubular PG and PGI2 a vascular PG. However, renal arterioles, tubules, medullary interstitial cells, and mesangial cells are able to produce both PGE2 and PGI2. PGE2 regulates sodium and chloride transport in the loop of Henle and modulates water transport and renal medullary blood flow. The physiological effects of PG2 are mediated through the four G-protein-coupled transmembrane prostaglandin receptors EP1, EP2, EP3 and EP4. PGI2 regulates renal vascular tone, GFR and renin release . In a person with normal renal hemodynamic parameters, PGs do not play a dominant physiologic role in maintaining renal blood flow and GFR . Selective COX-2 inhibitors were developed to produce the beneficial effects of NSAIDs, but spare the COX-1-mediated adverse events . However, COX-2 appears to be associated with renal vascular tissues and podocytes and has been implicated as the dominant COX at the macula densa and in the medullary interstitium. The identification of constitutive COX-2 in the human kidney , and the recognition of the profound effects of PGs on renal homeostasis may indicate that COX-2 inhibitors have the same potential for adverse renal effects as traditional NSAIDs . Therefore, the same precautions in patients at risk for adverse renal effects probably apply to both the nonselective NSAIDs and COX-2 selective inhibitors .

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Dosage For Gout Pain And Inflammation

Adult dosage


Immediate-release oral tablet

  • The initial dose is 750 mg, followed by 250 mg every 8 hours until the attack subsides.

Delayed-release oral tablet

  • The initial dose is 1,000 to 1,500 mg once daily followed by 1,000 mg once daily until the attack subsides.

Naproxen sodium:

Immediate-release oral tablet

  • The initial dose is 825 mg, followed by 275 mg every 8 hours until the attack subsides.

Child dosage

Dosage for people younger than 18 years hasnt been established.

Special dosage considerations

If youre older than 65 years, your body may process this drug more slowly. Your doctor may start you on a lowered dose so that too much of this drug doesnt build up in your body. Too much of the drug in your body can be dangerous.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.

Keeping Your Kidneys Safe When Using Pain Relievers

by akhealthfair | May 17, 2019 | News

Many analgesic medicines are available over the counter. These medicines are generally safe when taken as directed. However, their heavy or long-term use may harm the kidneys. Up to an estimated three to five percent of the new cases of chronic kidney failure each year may be caused by chronic overuse of these medicines. It is important to realize that, while helpful, these medicines are not completely without risk, and they should be used carefully. Kidney disease related to analgesics is preventable.

What are analgesics?

Analgesics are medicines that help to control pain and reduce fever. Examples of analgesics that are available over the counter are: aspirin, acetaminophen, ibuprofen, ketoprofen and naproxen sodium. Some analgesics contain a combination of ingredients in one pill, such as aspirin, acetaminophen and caffeine.

Can analgesics hurt kidneys?

Is aspirin safe for regular use?

When taken as directed, regular use of aspirin does not seem to increase the risk of kidney disease in people who have normal kidney function. However, taking doses that are too large may temporarily reduce kidney function. In people with kidney disease, aspirin may increase the tendency to bleed. People who already have reduced kidney function, or other health problems such as liver disease or severe heart failure, should not use aspirin without speaking to their doctor.

What analgesics are safe for people who have kidney disease?

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Kidney Damage From Naproxen:

Q. I am a 16-year-old girl who has had bladder problems since I was eight. I was taken to the hospital for pain in my left hip and the doctor prescribed two pills of naproxen to be taken twice daily.

I had pain in my stomach and back and couldnt sleep. Then my urinary system shut down completely. I had taken the drug for almost three weeks before another doctor took me off. I was in the hospital for seven weeks and was just released with no improvement.

I know the drug did this to me. Has anyone else had this severe reaction?

A. Nonsteroidal anti-inflammatory drugs such as naproxen can harm the kidneys . A study of marathon runners found that those who took ibuprofen before the race to ward off muscle soreness were more likely to develop temporary kidney failure as a result .

Most health professionals probably assume that seemingly healthy people, especially young adults, could not suffer worrisome kidney damage from a prescription for naproxen or ibuprofen. A meta-analysis of five studies published in the European Journal of Internal Medicine suggests otherwise. The authors reported an increased relative risk of acute kidney injury ranging from 58% to 211% among NSAID users.

In doctorspeak:

How Can Medication Damage The Kidneys

Naproxen (Aleve) Side Effects | Warnings For Hypertension & BP Meds & More

Your kidneys function as your bodys filter, ridding the body of toxins and waste while returning nutrients, vitamins, hormones, and other vital substances to the bloodstream. And because the kidneys receive such heavy volumes of your bloodstream, they are susceptible to damage caused by diabetes and high blood pressure. However, inappropriate medication use can also cause kidney damage.

When you take pain medication, your kidneys filter their active ingredients into your bloodstream so that they can begin working to ease your symptoms. But because medications like Ibuprofen block body chemicals that cause the blood vessels to dilate, this results in reduced blood flow to the kidneys reducing the blood flow helps stop pain from headaches and other afflictions, but it also means less oxygen passing through to keep the kidneys healthy and functioning properly. Some medications also cause excess water retention, which can put considerable strain on the kidneys. For people suffering from medical conditions like chronic kidney disease, NSAIDs can increase the risk of kidney failure.

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