Turmeric As An Alternative Therapy For Kidney Disorders
Turmeric is a famous Indian spice that has been revered in Traditional Chinese Medicine and Ayurveda as a herb to treat almost all disorders.
Curcuminoids are a class of compounds that are found in turmeric powder which impart the yellow color to the herb and are powerful antioxidants.
Curcumin is the principal curcuminoid that contributes to most of the turmerics pharmacological properties.
Compounds found in the volatile oil fraction of turmeric also possess therapeutic properties. The research studies mentioned below explain as to how turmeric can help treat kidney disorders.
Inflammation plays a very important role in the progression of kidney disease leading to kidney failure. Inflammation is characterized by the production of pro-inflammatory chemicals and migration of white blood cells to the site of injury or infection.
Tumor necrosis factor- alpha is the principal inflammatory mediator that activates a group of proteins called nuclear factor-kappaB. NF-kappaB regulates the inflammation process.
TNF-alpha decreases the expression of protein Peroxisome proliferator-activated receptor gamma and this further accelerates inflammation.
An experimental study was conducted to evaluate the role of curcumin in treating inflammation in kidney failure. A rat model of chronic renal failure was prepared by surgical removal of kidneys in rats.
The animals were divided into three groups: untreated, curcumin-treated and enalapril-treated groups.
Is Turmeric Good For Kidney Stones
As I mentioned above, turmeric powder is high in its oxalate content which might put people who are susceptible to developing kidney stones at risk if they have a dietary oxalate load that is already higher than it should be.
Hence, the turmeric in your diet is normally safe to eat for healthy individuals, however, if you are prone to developing kidney stones, it is important to keep an eye on the amount you consume throughout the day.
Limiting turmeric consumption to 1-2 tsp in a day would be ideal for people who are susceptible to kidney stone development.
How To Choose Your Turmeric Supplement
Supplements arent regulated like medications. Do your research on the company and brand you choose.
Turmeric extracts are the most potent type of supplement. Concentrated extracts are 95% curcumin. Powders and spices contain a lot less of the potent ingredient.
Extracts also have less chance of contamination from other substances.
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Side Effects Of Turmeric
Turmeric contains oxalates and this can increase the risk of kidneys stones. The consumption of supplemental doses of turmeric can significantly increase urinary oxalate levels, increasing risk of kidney stone formation in susceptible individuals.
How turmeric can be good for kidney disease?
There is a reasonable amount of evidence to suggest that curcumin in turmeric contains anti-inflammatory and antioxidant properties, which have been shown to slow down the progression of severe kidney diseases like CKD.
Another study done in 2016 suggests that because of the antioxidant and anti-inflammatory content, turmeric may also help reduce the inflammatory markers in people undergoing haemodialysis and in reducing the overall risk of developing kidney diseases.
What is the main medicinal ingredient in turmeric?
Curcumin is the main medicinal ingredient in turmeric. Curcumin is also responsible for giving turmeric its yellow colour.
Because of the active compound curcumin, turmeric was used historically in traditional Chinese medicine and India as Ayurveda as a treatment for digestive issues, upper respiratory tract and cuts and sores. Turmeric is also used as a paste for skin conditions.
Can curcumin damage your kidneys?
Curcumin/turmeric is safe to consume and would not cause any damage to the kidneys. However, for a person who is prone to develop kidney stones, eating a lot of turmerics may increase the chances of developing kidney stones.
Is turmeric good for kidney stones?
Is It Safe To Use Herbal Supplements If I Have Kidney Disease
You may think about using herbal supplements to help with any health concerns you may have, but as a patient with kidney disease, you should use caution with herbal supplements.
Use of herbal supplements is often unsafe if you have kidney disease since some herbal products can cause harm to your kidneys and even make your kidney disease worse. Also, your kidneys cannot clear waste products that can build up in your body.
The herbal supplement market is a multi-million dollar business. You may hear from a friend or family member about an herbal supplement that they think has improved their health or well-being and they suggest it to you. While this advice may be fine for them, it can be dangerous for you with kidney disease.
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/7the Safe Amount Of Turmeric
As per science, having 5002,000 mg of turmeric per day in an extract form may have potential benefits. In extract form, the curcumin content is generally higher than the amounts naturally occurring in foods.
If you add 2,0002,500 mg of turmeric in your food, it provides only 60100 mg of curcumin per day. This amount of curcumin intake is not harmful to anyone. However, if you are planning to take curcumin supplements then consult your doctor first.
Disclaimer: The views expressed in this article should not be considered as a substitute for physician’s advice. Please consult your treating physician for more details.
Is It Good To Drink Turmeric Water In Empty Stomach
It contains powerful anti-inflammatory effects and is a very strong antioxidant. It is believed that drinking turmeric tea or warm turmeric water on an empty stomach can effectively help your body burn excess flab. Turmeric being a very potent antioxidant agent is not just a herb used for your culinary delights.
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Turmeric A Powerful Weapon Against Kidney Disorders
Human body derives energy from the food, oxygen and other supplements introduced in the system. As by-product waste materials are produced which require to be eliminated from the body.
Kidneys play a vital role in excretion. These organs are found below the abdominal cavity and they excrete urine through the bladder.
Excretion is their prime function but the other activities that the kidneys influence are:
- Absorption of nutrients: Apart from excreting wastes, the kidneys filter the blood and reabsorb certain molecules like glucose and ions such as sodium, calcium, and potassium.
- Blood pressure regulation: By absorbing sodium and influencing its concentration in the system, kidneys indirectly regulate blood pressure.
- Maintaining pH levels of blood
- Secretion of hormones
Just like every other organ, the kidney is susceptible to infection, damage or failure.
Kidney disorders can be present in an individual by birth such as polycystic kidney disease or can be acquired over time either due to an infection or as a result of another metabolic disease such as diabetes.
Humans can survive with just one kidney which makes it possible to transplant kidneys to those who require well functioning renal tissue.
Dialysis, medications, kidney transplant are a few of the treatment options available for kidney disorders.
Should Turmeric Be Avoided Altogether
No, turmeric can still be included in the diet in various foods. In diet, turmeric is usually present in low amounts, which provides very low concentrations of oxalates and minerals.
This is unlikely to have any significant effects on kidney health.
However, if you have kidney stones, avoid high or supplemental doses of turmeric.
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Effect Of Curcumin And Enalapril On Macrophage Infiltration
Deterioration of renal function and marked inflammation in Nx animals are associated with significant macrophage infiltration in the kidney . displays representative photomicrographs of macrophage infiltration for each experimental group, and the results are summarized in . Kidneys from control animals did not show significant macrophage infiltration, but Nx animals demonstrated prominent macrophage infiltration in the glomerulus and tubulointerstitium . Nx animals treated with curcumin and enalapril showed a reduction of macrophage influx by 53 and 43%, respectively . Although enalapril-treated animals showed a greater reduction in macrophage infiltration than curcumin-treated animals, the difference is not statistically significant.
Fig. 3.Macrophage influx in the kidney of control, sham-operated untreated 5/6 nephrectomized rat, curcumin-treated 5/6 nephrectomized rat, and enalapril-treated 5/6 nephrectomized rat. Macrophages were observed in the glomerulus and tubulointerstitium of Nx animals. A: representative photomicrographs of macrophage infiltration for each experimental group. B: macrophage influx was quantified by F4/80-positive cells. The number of macrophages was significantly decreased in Nx rats treated with curcumin and enalapril. The bar graph is the average of 4 randomly selected fields of view for each animal and expressed as total integrated optical density. Values are means ± SD n = 6 animals/group **P< 0.01, ***P< 0.001 compared with Nx.
Thedrugs And Supplements That Should Cause Concern
The following drugs andsupplements can affect kidney function:
NSAIDs are very effectivemedications for multiple medical problems. But taking NSAIDS can affectthe kidneys, and can cause damage, especially if youre also takingdiuretics or ACE inhibitors.
NSAIDS include over-the-counterpainkillers like aspirin , ibuprofen , and naproxen .
They also includeprescription drugs like:
- Naproxen sodium .
- Naproxen/esomeprazole .
- Diclofenac .
Using these medications withcaffeine can further harm your kidneys. When taking these medications, be sureto check regularly with your doctor if you have impaired kidney function.
Certain antibiotics areremoved from the body through the kidneys, so taking them can put extra strainon your kidneys. Penicillin, cephalosporins and sulfonamides in particular canbe harmful to your kidneys.
Long-term antibiotic use caninjure your kidneys, even if youre otherwise healthy. And for people whosekidneys arent functioning at 100% to begin with, antibiotics can build up inthe body and cause damage.
Despite this, its importantto keep in mind that antibiotics can be safely used if needed as long as thedose is adjusted for your bodys level of kidney function.
3. Dietary supplements
Certain herbs or nutritionalsupplements are associated with kidney injury, even among healthy people. Withsuch a wide variety of supplements available, the best way to know if asupplement is safe is to ask your doctor to review all the ingredients.
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Medications That Slow Blood Clotting Interacts With Turmeric
Turmeric might slow blood clotting. Taking turmeric along with medications that also slow clotting might increase the chances of bruising and bleeding.Some medications that slow blood clotting include aspirin, clopidogrel , diclofenac , ibuprofen , naproxen , dalteparin , enoxaparin , heparin, warfarin , and others.
How Many Teaspoons Of Turmeric Should You Take A Day
How much turmeric should you consume to retain the health benefits? Here are a few helpful tips to get you started. Sayer uses 1/2 1.5 teaspoons per day of the dried root powder, certified organic. A typical dose of supplemental curcumin is about 250mg per day, and often increased when dealing with a condition.
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How To Take Turmeric For Pain
Turmeric in Indian and Asian cooking is a long-standing tradition.
A typical Indian diet supplies 2,000 to 2,5000 mg of turmeric per day. That equals 60 to 100 mg of curcumin. If you ingested the same quantity of turmeric as an extract it would be 1,900 to 2,375 mg of curcumin.
The spice has about 3% curcumin. Turmeric extract has 95% curcumin. Adding turmeric to your food provides some benefits, but not as much as a supplement.
Most studies use a turmeric extract. The typical study dose of 500 to 2,000 mg of turmeric per day had potential benefits. The exact dose depends on the medical condition.
The Arthritis Foundation suggests taking turmeric capsules 3 times per day. Another option is to take a half to three grams of the root powder every day.
Further studies revealed one gram of curcumin per day helped arthritis patients.
One issue with turmeric is its hard for the body to absorb the spice by itself. Nutritionists suggest mixing the spice with black pepper and olive oil to help your body absorb it.
The amount of turmeric used in normal cooking is safe. But dont assume more is better. High doses can cause nausea, diarrhea, and dizziness.
The World Health Organization found 1.4 mg of turmeric per pound of body weight is okay for daily intake. Its not advisable to take high doses of turmeric for long periods of time. There isnt enough research to guarantee safety.
Can You Take Turmeric Everyday
The World Health Organization found 1.4 mg of turmeric per pound of body weight is okay for daily intake. Its not advisable to take high doses of turmeric for long periods of time. There isnt enough research to guarantee safety. If you want to take turmeric to relieve pain and inflammation, talk to your doctor.
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Turmeric Is Bad For Kidney
Turmeric is among those superfoods that has actually taken the natural health world by storm. While most people could utilize this seasoning to add taste to curries, health and wellness enthusiasts make use of turmeric for its lots of supposed health advantages. Simply a few of the researched benefits include supporting a healthy body immune system, sustaining muscle and also joint health and also supporting healthy and balanced cognitive feature.Turmeric Is Bad for Kidney
This made me begin to think of exactly how I can begin to experience several of the advantages of turmeric extract As a result of turmerics hype, you can get your fix of turmeric extract in lots of types. Im a massive follower of turmerics examined benefits not its smell or taste. Lathering myself in turmeric soap or having a turmeric-ginger tea wasnt precisely my favorite in itself, however thats not too much of an issue when I found out that supplemented turmeric extract may really be a lot more reliable than raw turmeric extract. Hear me out.Turmeric Is Bad for Kidney
Effect Of Curcumin On Ppar In Mesangial Cells
To investigate whether curcumin can directly affect PPAR expression, rat mesangial cells were incubated with curcumin concentrations ranging from 1.25 to 20 M. , A and B, shows that curcumin dose dependently increased the PPAR mRNA and protein in a dose-dependent manner. A significant increase in PPAR protein expression was observed with curcumin concentrations of 5 M and above, suggesting that curcumin mediates its effect by increasing PPAR protein and thereby negating the downregulation of PPAR brought about by TNF-. As shown earlier , curcumin significantly antagonized the TNF-mediated decrease in PPAR. In the absence of TNF-, we expected lower concentrations of curcumin to increase expression of PPAR. However, reduced concentrations of curcumin did not affect PPAR protein expression significantly.
Fig. 7.Curcumin increases PPAR mRNA and protein in mesangial cells. To investigate the effect of curcumin on PPAR, mesangial cells were incubated with increasing concentrations of curcumin dissolved in ethanol for 24 h. The control cells received the vehicle. Cells were treated with increasing concentrations of curcumin. PPAR mRNA was normalized to -actin and was compared with control . A: curcumin dose dependently increased PPAR mRNA. B, top: representative Western blot of 4 experiments. PPAR protein immunoblots were normalized to -actin. The results were compared with control cells.*P< 0.05, **P< 0.01.
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/7when Suffering From Anaemia
Anaemia is caused due to iron deficiency. It occurs when the body does not make enough red blood cells or the body loses excessive red blood cells due to bleeding or it destroys red blood cells. Taking turmeric in high concentration in such a situation can prevent the absorption of iron, making the condition worse.
Effect Of Curcumin On Ppre And Nf
In the earlier experiment, we observed that curcumin directly upregulated PPAR expression causing a physiological antagonism. However, curcumin might also abrogate the effect TNF- on PPAR, by interfering at the transcriptional level. The promoters of PPAR target genes consist of PPRE, a direct repeat of two hexanucleotides spaced by one nucleotide , through which PPAR can bind to and activate target gene expression . Transcription factor PPAR binds to PPRE of the target gene promoters in nucleus, leading to regulation of gene expression . To determine whether TNF- affects PPAR-mediated transactivation of PPRE, mesangial cells were transiently transfected with a PPRE-luciferase reporter construct. Twenty-four hours later, the cells were treated with TNF- in both the presence and absence of curcumin. As shown in , TNF- decreased PPRE activity by 50%, an effect which curcumin reversed in a dose dependent manner.
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Determination Of Serum Biochemical Parameters
Serum total cholesterol, triglycerides, HDL-cholesterol, NEFA, urea nitrogen, albumin and creatinine were estimated as described earlier using the commercial diagnostic kits following the manufacturers instructions. Serum VLDL and LDL-cholesterol were calculated indirectly by the Friedewalds equations.
VLDL=Triglycerides/5 LDL=Total-cholesterol .
Atherogenic index and coronary risk index as measures of the extent of atherosclerotic lesions and coronary atherosclerosis development, respectively, were calculated using serum total cholesterol and HDL cholesterol of different groups of rats using the mathematical formulae below .
AI=/HDL CRI=Total cholesterol/HDL.
Protect Against Skin Diseases That Cause Kidney Diseases
A variety of kidney diseases are caused by infections on the skin. Both the skin and the kidneys play very vital roles when it comes to the excretion of urea.
Once the skin is infected and unable to perform there functions as required, it lives the kidney overloaded with work which might impair with the correct functioning of the kidneys leading to kidney disorders.
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Turmeric In Kidney Cancer
Some studies indicate that turmeric may promote anti-cancer effects in people suffering from kidney cancer.
A study done in 2019 demonstrated that curcumin stopped the growth of cancer cells in the bone and promoted the growth of healthy cells as well.
However, a lot more evidence is needed to say anything definitely about turmeric when it comes to kidney cancer.
Is Turmeric Tea Good For Kidney Disease
Turmeric tea can be helpful for kidney disease patients as it might help the kidneys in expelling out the toxic wastes from the body.
Turmeric tea may also be helpful for people suffering from polycystic kidney disease as the studies show that curcumin inhibits the growth of cyst formation in patients with PKD .
Polycystic kidney disease is an inherited disorder that can lead to the development of numerous cysts in the kidneys. The cysts are fluid-filled sacs that can cause swelling in the abdomen.
Evidence suggests that curcumin was able to demonstrate significant inhibition of the development of these fluid-filled cysts, which means it slowed down the cyst formation.
Again, a lot more further research is needed on this topic but the initial studies have indicated a positive result when it comes to turmeric and kidney diseases like PKD.
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