Data Source And Search Strategy
MEDLINE, EMBASE and CENTRAL databases were searched for English-language articles without time restriction up to 28 December 2012 through focused, high sensitive search strategies . References from relevant studies and reviews published on the same topic were screened for supplementary articles. The search was designed and performed by one Author and independently re-assessed by another .
Data Extraction And Analysis
Data extraction and analysis were performed by one reviewer and independently verified by another reviewer . In studies considering mixed populations, the subgroup of patients with documented impaired renal function was considered for analysis only if corresponding data were available. Data reported as median and range were converted to mean and SD by using the formula by Hozo .
Blood Urine And Clinical Measurements
Blood biomarkers were analyzed in Leipzig University Laboratories, Leipzig, Germany. A blood sample was drawn by venipuncture at 8:00 a.m., after a 12-h fast, at baseline, and at 6 and 24 months and stored at 80°C. Spot urinary creatinine and albumin were measured with enzymatic assays using the automated Roche/Hitachi Cobas System . Plasma insulin, serum high-sensitive C-reactive protein, total, HDL-, and LDL-cholesterol, triglycerides, leptin, and total high-molecular-weight adiponectin, apolipoprotein A1 , and apoB100 were measured as described previously . Body weight was measured to the nearest 0.1 kg every month without shoes. Height was measured to the nearest millimeter with the use of a wall-mounted stadiometer at baseline for BMI determination. Blood pressure was measured every 3 months with the use of the DatascopAcutor 4 automated system after 5 min of rest.
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Kidney Function And Kidney Disease
The primary task of the kidneys is to maintain the fluid balance in the body. They accomplish this task through increasing or decreasing the amount of fluid excreted in the urine. Electrolytes like sodium and potassium are an important component of fluid management. When you eat or drink liquids, the fluid eventually makes its way to the kidneys. A complex mechanism of fluid and electrolyte transfers, mediated by hormones and other chemicals, results in the movement of fluid into the kidneys and bladder, from which the urine is excreted. Kidney disease damages these mechanisms.
This Wasnt The Life I Wanted
I felt very low, to be honest.
My doctor gave me the standard spiel: we can handle the symptoms, we can try to address underlying causes with the right meds I could lead a fairly normal life. And so on.
I told him this wasnt good enough. I didnt want my life cut short with a disease that at least officially had no way of being reversed.
I didnt want to watch myself deteriorate week by week. I didnt want to be plugged into a dialysis machine. I didnt want a transplant.
And I didnt want to die early.
I was very upset. I didnt know what to do next.
But I didnt want to just do nothing.
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Late Kidney Disease Or Kidney Failure
Untreated kidney disease will usually progress to complete kidney failure. The kidneys simply stop functioning or function so poorly that they cannot keep with the work of fluid management. Fluid builds up in the tissues, causing swelling and weight gain. Its important to recognize that this is water weight, not fat or muscle. In fact, many people with severe kidney disease or kidney failure are actually undernourished. The excess swelling can make it difficult to breathe and increase your blood pressure.
Effect Of Different Weight Loss Interventions
Bariatric surgery
Bariatric surgery reduced BMI or body weight in all studies . The entity of BMI decrease was not quantified in the study by Schuster . GFR decreased in four studies on obese patients with hyperfiltration and in another two where hyperfiltration was apparently not present . On the contrary, in the retrospective analysis by Navaneethan including 25 obese patients with CKD Stage 3, eGFR increased after surgery from 47.9 to 56.6 mL/min/1.73 m2 at 6 months and 61.6 mL/min/1.73 m2 at 1 year. Creatinine decreased in the studies by Brøchner-Mortensen , Navarro-Diaz , Navaneethan , and in the case series of patients by Wesley-Alexander . In the study by Schuster , creatinine decreased in patients with baseline mild renal impairment and increased in those with moderate renal impairment . In the study by Agrawal , creatinine did not change but patients had normal values at baseline. Albuminuria decreased in six studies . Agrawal described a significant reduction in albuminuria only in diabetic patients and in those with metabolic syndrome. In the study by Navaneethan , albuminuria significantly decreased only in patients with pre-existing microalbuminuria and in those undergoing Roux-en-Y gastric bypass. Proteinuria was reduced after surgery in all five studies in which the measurement was performed prepost weight loss .
Adverse effects reported
Diet
Antiobesity drugs
Adverse effects reported
Exercise alone
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Is 30 Percent Kidney Function Bad
An eGFR between 15 and 30 means your kidneys are moderately or severely damaged and are not working as they should. Stage 4 kidney disease should be taken very seriously it is the last stage before kidney failure. At Stage 4 kidney disease, many people have symptoms such as: Swelling in your hands and feet.
Commit To Staying Active
People who exercise consistently are stronger and have more energy. However, you should check with your doctor before you begin an exercise program.
There are a few things you should know before you get started. First, choose a continuous activity that you might enjoy like walking, swimming, biking , or aerobic dancing. Build up gradually to 30-minute sessions at least three days a week. Youll be more successful if you stick to a schedule .
Dont forget to pay attention to your body. Start out slowly with a warm-up then pick up your pace. End with a cool down. Remember, you should still be able to talk with someone while exercising. If you cant, youre overdoing it. If you begin to feel chest pain, cramps, dizziness, or shortness of breath, its time to stop.
Kidney Maintenance
While March is National Kidney Month, you can commit to keeping your kidneys healthy year-round. Always be mindful of:
- Maintaining a blood pressure below 140/90
- Staying in your target blood sugar range, if youre diabetic
- Committing to staying active
- Losing weight with healthy diet choices
- Getting tested for kidney disease if youre at risk
- Taking medications as instructed by your doctor
- If you smoke, quit
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Does Losing Weight Affect Your Kidneys
Weight loss can affect your kidneys, sometimes in unpredictable ways. If you already have kidney disease, your doctor may suggest that you gain weight or avoid losing weight. But for people with conditions that threaten the kidneys as a secondary complication, such as high blood pressure or diabetes, weight loss may be prescribed. Finally, both extreme weight gain and extreme weight loss can put you at risk for kidney stones. Your physician can recommend sensible plans to help you achieve the weight goal most appropriate to your condition.
Renal Function Following Three Distinct Weight Loss Dietary Strategies During 2 Years Of A Randomized Controlled Trial
A.T. and R.G. contributed equally to this work.
Diabetes Care
Amir Tirosh, Rachel Golan, Ilana Harman-Boehm, Yaakov Henkin, Dan Schwarzfuchs, Assaf Rudich, Julia Kovsan, Georg M. Fiedler, Matthias Blüher, Michael Stumvoll, Joachim Thiery, Meir J. Stampfer, Iris Shai Renal Function Following Three Distinct Weight Loss Dietary Strategies During 2 Years of a Randomized Controlled Trial. Diabetes Care 1 August 2013 36 : 22252232.
This study addressed the long-term effect of various diets, particularly low-carbohydrate high-protein, on renal function on participants with or without type 2 diabetes.
In the 2-year Dietary Intervention Randomized Controlled Trial , 318 participants with serum creatinine < 176 mol/L were randomized to low-fat, Mediterranean, or low-carbohydrate diets. The 2-year compliance was 85%, and the proportion of protein intake significantly increased to 22% of energy only in the low-carbohydrate diet . We examined changes in urinary microalbumin and eGFR, estimated by Modification of Diet in Renal Disease and Chronic Kidney Disease Epidemiology Collaboration formulas.
We therefore investigated the long-term effect of low-fat, Mediterranean, and low-carbohydrate dietary intervention strategies on renal function among overweight or obese people with or without type 2 diabetes and pre-existing mild to moderate renal dysfunction in the Dietary Intervention Randomized Controlled Trial .
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Cutting To The Chase: What Do I Do Next
So my doctor is explaining all this over coffee well, three coffees to be accurate.
It was a heck of a lot to take in.
It all led to one obvious question though: how do I go about applying all this to myself?
How does an ordinary person like me make use of all this powerful stuff?
My doctor told me he knew of a health practitioner who had turned these new insights into a series of steps for sufferers to follow.
The program showed them a way out of their suffering all described in plain English.
He had already recommended the program to other kidney patients. And those who followed it enjoyed life-changing results.
Thats exactly what I wanted.
I wanted something I could do something that I knew others had successfully completed.
Something that had successfully addressed their diseased kidneys.
Transplant For Kidney Disease
Transplantis considered the gold standard for end stage kidney failure treatment. You can apply to be on the kidney transplant waiting list if your kidney function isat or below 20%.
The average waiting time for a kidney transplant isapproximately 3 to 5 years, so its important to get on the waitlist as soon as possible. Once on the waitlist, monthly blood tests will be done to monitor your kidney function.
After a kidney transplant, a transplant team will follow up and closely monitor your kidney function. There will be life-long anti-rejection medications that will need to be taken to prevent the kidney from being rejected by your body.
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The Chance To Turn It All Around
Get those gut bacteria healthy and everything that was going wrong including serious kidney illness starts going right again.
But what causes our guts to become unhealthy?
Theres no doubt at all about the causes: its our lifestyle choices.
Lifestyle simply refers to the usual suspects: stress, sleep, fitness and diet.
Which, at first sight, all seems pretty bland and dull. Weve heard all this before.
But now its very different. Because now scientists understand the direct link between what we do and how we get disease.
Poor lifestyle habits slowly ruin our gut health. They decimate good bacteria allowing bad bacteria to thrive and expand their deadly effects.
Our gut environment becomes less helpful to us and steadily more deadly.
Which makes it inevitable that, in time, we will end up either very ill or fatally ill.
The damage that bad habits do to our gut bacteria is almost the entire reason we are tired, ill, overweight, suffer low moods and struggle as we get older.
We say its age that causes disease. Thats absolute nonsense.
Its the slow and steady neglect of our gut health that causes disease. We do it to ourselves. We dont mean to. But its what we do.
Poor lifestyle habits are the primary reason we contract western societys worst diseases heart, blood, liver, kidney
Our basic lifestyle habits directly and dramatically determine whether well be ill at all.
Do Fat Burners Affect Kidneys
Do diet burners affect the kidney?, fat burners contain elements like ephedra which ensure rapid weight loss, this substance was banned in the US because of its side effect of causing kidney stones and other kidney malfunctions. Manufacturers still modify these ephedra molecules which give similar effects and side effects. The fact surrounding most fat burners makes it a bad choice in weight loss, the bodys physiologic sequence is altered and this leads to resultant negative effects on the cells of the body and organs .
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Healthy Weight Loss With Kidney Disease
For those with a overweight or obese body mass index , your doctor may encourage some weight loss to help manage your kidney disease.
Healthy weight loss is generally seen as weight loss of one to two pounds per week. For those with over 100 pounds of weight to lose, aiming for approximately 1% weight loss per week may be acceptable.
Benefits of Kidney Disease and Weight Loss
Intentional weight loss has been shown tohelp preserve kidney function for those that have type 2 diabetes and kidney disease.
Other benefits that have been found with weight loss for kidney disease includeless protein in the urine and lower systolic blood pressure.
Causes Of Kidney Disease
There are many causes of CKD, which is why it has become so prevalent in the United States. And while some are very familiar, not all are known.
Diabetes
The top cause of CKD is diabetes. Diabetes affects over 11% of the US population as of 2022. Prediabetes affects even more 96 million people have diagnosed prediabetes.
Whether its type 1, type 2, or even pre-diabetes, uncontrolled blood sugar can cause damage to the delicate kidney filtration system in your body.
For a diabetes diagnosis, a blood test of your glucose is usually the first step. A fasting blood sugar of over 126 mg/dL in two separate tests can confirm a diagnosis of diabetes.
Another type of blood test is thehemoglobin A1c . An A1c of between 5.7 and 6.4% is classified as prediabetes. An A1c of 6.5% or greater is classified as a diabetes diagnosis.
Type 1 diabetes is also called juvenile diabetes as it is discovered in the early stages of childhood. This is due to the fact that the pancreas does not produce any insulin.
Type 2 diabetes, or adult onset diabetes, is typically diagnosed in adulthood. It is caused by a poor response to the insulin that is produced by the pancreas.
Hypertension
High blood pressure, otherwise known as hypertension, is the second top cause of kidney disease in the United States.
In 2017, the American Heart Association changed the blood pressure guidelines to become more strict in when to define a blood pressure as being excessive.
Glomerulonephritis
Autoimmune Diseases
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Icipants And Study Design
This prospective, open-label intervention study included 23 obese patients all scheduled for RYGB at Hvidovre University Hospital, Denmark. Three patients never had the surgery performed and one patient declined to participate in the post-surgery visit. Therefore, a total of 19 patients completed the study. Type 2 diabetes was diagnosed according to the WHO criteria.
Patients were recruited from March 2014 and the study was completed in June 2016.
The study design is illustrated in Fig. . Patients attended the baseline visit within two weeks prior to the scheduled RYGB and the follow-up visit was performed six months after RYGB.
Fig. 1
The study protocol was approved by the regional ethics committee and was conducted according to the Declaration of Helsinki. All patients gave written informed consent before any study procedure was initiated. The study is registered at ClinicalTrials.gov with identifier NCT02138565. The two study-related visits were conducted at Steno Diabetes Center, Gentofte, Denmark, and the RYGB was performed at Hvidovre University Hospital, Hvidovre, Denmark as described previously .
The primary aim was to assess the effect of a large weight reduction on measured GFR and on estimated GFR . Secondly, we assessed the effect on body composition in order to relate these changes with changes in renal outcome measures.
What Does It Mean When Your Kidney Function Is Low
The kidneys are organs near your back on each side of the spine. They are the size of your fists and contain structures called nephrons.
These are formed by different types of cells, creating a tubular form through which blood components go in and out. After the exchange of substances that happens in the nephrons, your kidneys will produce urine.
Low kidney function is a reduction of nephron activity in the kidneys. This can be due to an autoimmune disease such as glomerulonephritis.
Regardless of the cause, the nephrons are damaged and stop filtering blood in most cases. Sometimes that makes the affected kidney like a broken colander, and patients start throwing protein in the urine.
The glomerular filtration rate indicates how your kidneys work. In chronic kidney disease, this measure drops gradually, and the late stage of the disease is characterized by complete anuria.
In other words, patients can no longer urinate. They need kidney support to perform their functions through dialysis.
Then, how to take care of your kidneys and prevent this from happening? Before discussing how to keep your kidneys healthy, how can you be sure kidney function is affected?
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Why Does Kidney Disease Cause Weight Gain
Kidney disease doesnt just affect the kidneys, it affects the whole body. In the early stages, it can cause weight loss, while in the later stages it can cause weight gain. These variations are the result of different aspects of the disease. Heres some information to help you understand the issue of kidney disease and weight gain, courtesy of Dr. Allen Lauer, of Associates in Nephrology.
Can Losing Weight Improve Kidney Function
Weight loss can improve kidney function, the classic question most ask is whether losing weight improve kidney function, the answer is absolutely positive because the good weight is good for the heart which supplies the kidney. The brain and the vessels too are kept safe and not overstressed.
Weight loss reduces proteinuria, which is excess protein in the urine thereby reducing the workload of filtration channels and progression of existing kidney malfunction.
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