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Is Codeine Bad For Kidneys

Is Overdose With Acetaminophen Usually Accidental Or Intentional

Opioids in Liver and Kidney Disease

In the U.S., suicide attempts account for over two thirds of acetaminophen-related liver injury, whereas accidental overdose accounts for only one third of the cases. In young children, accidental overdose accounts for an even lower percent of the cases. Among these often-curious toddlers, accidental overdose is responsible for less than 10% of the instances of acetaminophen toxicity. The vast majority of these accidental overdoses were due to unintentional overdoses given by the caregivers of the children.

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How To Safely Take Tylenol

If used in physician recommended doses, taking Tylenol is safe, even for most people with liver disease who do not drink alcohol. Liver damage from Tylenol can depend on several factors. Some of them are:

  • The amount of Tylenol you take
  • The amount of alcohol you drink
  • If you take other medications with Tylenol. Some drugs, including opiods, dilantin, and others, may interact poorly with Tylenol and increase the risk of liver damage certain herbal supplements can also interact with Tylenol and cause liver damage.
  • Your level of nutrition
  • Being a smoker

Key Points About Analgesic Nephropathy

  • Long term use of pain killers can cause damage to the kidneys. This includes over-the-counter and prescription pills.
  • This condition is most common in people older than 45 years of age, and more prevalent in women over 30.
  • Often there are no symptoms. It may be found on routine blood or urine tests.
  • Symptoms are related to the build-up of toxins and waste products that are normally filtered by the kidneys.
  • Analgesic nephropathy can lead to acute kidney failure, cancer, or atherosclerosis in later stages.

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What Happens If I Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A codeine overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose can cause severe muscle weakness, cold and clammy skin, pinpoint pupils, very slow breathing, extreme drowsiness, or coma.

Pharmacokinetics In Organ Impairment

Kidney Damage Tylenol

The pharmacokinetics of a drug depends on patient-related factors as well as on the drugs chemical properties. Some patient-related factors can be used to predict the pharmacokinetic parameters in a given population. Variability in these parametersabsorption, distribution, metabolism, and excretionmay occur in patients with hepatic and renal impairment. Vital aspects of opioid pharmacokinetics will be discussed in the subsequent sections.

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Nsaids Are Bad For Your Blood Pressure

NSAIDs can cause high blood pressure. And if you have high blood pressure, they can make it worse. This increases your chances of having a heart attack or a stroke.

NSAIDs can also keep some blood pressure drugs from working right. NSAIDs can interfere with:

  • Diuretics, or water pills, such as Hydrodiuril . Diuretics remove excess water from the blood vessels.
  • ACE inhibitors, such as Prinivil and Zestril . ACE inhibitors are drugs that relax the blood vessels.
  • ARBs such as Cozaar . ARBs are another group of drugs that relax the blood vessels.

Which Painkillers Can You Use If You Have Heart Or Kidney Disease

There is no simple answer. The best painkiller to use depends on your health problems. It also depends on any other drugs you take. Be sure to tell your doctor about any prescription drugs, over-the-counter drugs, or herbal medicines you take.

Over-the-counter Tylenol is often the best choice for people with high blood pressure, heart failure, or kidney problems.

  • However, high doses of Tylenol can damage the liver, so take the lowest dose you can to get enough pain relief.
  • Never take more than 4,000 milligrams a day. Thats equal to twelve 325 mg pills.

If Tylenol or generic acetaminophen do not work, ask your doctor about using a stronger prescription painkiller, such as Ultram for a short time.

  • If you have kidney problems, do not take more than 200 mg a day. And take it once every 12 hours to limit the risk of side effects.
  • Do not use tramadol if you have epilepsy or if you take Paxil , Prozac , or Zoloft . Taking tramadol with these drugs can increase your risk of seizures.

This report is for you to use when talking with your healthcare provider. It is not a substitute for medical advice and treatment. Use of this report is at your own risk.


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What Are The Risks Associated With Codeine

Opioids are strong pain medicines and can cause life-threatening breathing problems.

If you take codeine, you may become dependent on this medicine even if you take it exactly as prescribed by your doctor. Your doctor will monitor how you use codeine, to reduce your risk of harm, including through misuse, abuse and addiction.

You can also develop tolerance when you take codeine this means that you may need to take larger amounts of the opioid to get the same effect. As the dosage increases, so does the risk of side effects.

Continue to take codeine for as long as your doctor tells you to. If you stop taking codeine suddenly, you may experience withdrawal symptoms.

Codeine may make it difficult for you to drive or operate heavy machinery. If you have recently started taking codeine or another opioid medication, or the dosage has changed, you may be at higher risk of having an accident.

If your kidney or liver function is impaired, your doctor may decide that codeine in not appropriate for you. There are other factors that may limit your use of codeine for example, if you drink alcohol or take other medicines that can cause drowsiness.

Your doctor is the best person to advise you on whether codeine is the right medicine for you, how much you need and how long to take it for.

Important Information About All Medicines

Codeine Conversations: Chronic Pain

Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.

This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.

Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.

If you have any questions about this medicine ask your pharmacist.

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Other Clinical Findings With Opioid

In the gastrointestinal tract, opioids reduce propulsive peristaltic contractions, and increase muscle tone and intraluminal pressure by decreasing the release of acetylcholine in the ileum . In the setting of acute opioid intoxication and AKI, potassium exchange resins as a treatment for hyperkalemia that work in the gastrointestinal tract have limited effectiveness and need to be used with caution .

Before Taking This Medicine

You should not use this medicine if you are allergic to it, or if you have:

  • severe asthma or breathing problems

  • a blockage in your stomach or intestines or

  • frequent asthma attacks or hyperventilation.

In some people, codeine breaks down rapidly in the liver and reaches higher than normal levels in the body. This can cause dangerously slow breathing and may cause death, especially in a child.

Do not give codeine to anyone younger than 18 years old.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

  • enlarged prostate, urination problems or

  • mental illness, drug or alcohol addiction.

Some medicines can interact with codeine and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take stimulant medicine, herbal products, or medicine for depression, mental illness, Parkinson’s disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications.

If you use this medicine while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Tell your doctor if you are pregnant or plan to become pregnant.

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Common Questions About Co

Co-codamol contains paracetamol and codeine. These 2 painkillers work in different ways to relieve pain.

Paracetamol seems to work by blocking “chemical messengers” in the brain that tell us we have pain. It also reduces a high temperature by affecting the chemical messengers in an area of your brain that controls body temperature.

Codeine belongs to a group of medicines called opiates. It affects pain receptors in the central nervous system and the brain to block pain signals to the rest of the body. When codeine blocks the pain receptors, there are other unwanted effects for example slow and shallow breathing. It can also slow down digestion, which is why codeine can cause constipation.

Co-codamol takes up to 1 hour to work. It keeps on working for about 5 hours.

If you’ve bought co-codamol from a pharmacy, do not use it for more than 3 days. If your pain has not gone away, talk to your pharmacist or doctor.

If your doctor has prescribed co-codamol for you, take it as you’ve been advised. Depending on why you’re taking it, you may need to take it for a few days or weeks at most. For example, if you’re in pain after an injury or operation.

You may need to take it for longer if you have a long-term condition such as back pain.

Talk to your doctor if you’re not sure how long you need to take co-codamol for.

It’s possible to become addicted to co-codamol. For this reason, your dose will be reviewed to make sure you are only taking the amount you need to control your pain.

Treating Pain In Patients With Chronic Kidney Disease: A Review Of The Literature

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Patients with chronic kidney disease often suffer from chronic pain. It may be difficult to select appropriate analgesic therapy in this population because many patients require complex medication management for the comorbidities that accompany renal disease. A reduced glomerular filtration rate alters the normal pharmacokinetics of analgesic medications and increases the potential for toxicity, undesirable side effects, and drug interactions. Appropriate analgesic selection, dose titration, and monitoring are critical for the successful management of this population.

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Risks Related To Codeine Use

Even the use of lower-dose codeine medications over an extended period can cause dependence, problematic use, risk of slowed breathing, and death.

As products with codeine are often combined with other medicinal ingredients, some of the risk comes from the acetaminophen or acetylsalicylic acid in the product, which are associated with liver and kidney toxicity or gastrointestinal bleeding, especially when taken at higher than recommended doses.

Like other opioids, codeine use carries a risk of overdose and poisoning if you consume more than recommended. Symptoms of overdose include:

  • unresponsiveness

In cases of overdose, you can use naloxone to temporarily reverse the effects of codeine and other opioids. It must be given as soon as possible, no more than 20 to 30 minutes after the codeine has been taken.

Staying at the scene of an overdose is important to help save the life of the person overdosing. The Good Samaritan Drug Overdose Act gives some legal protection for individuals who witness an overdose and call 911 or their local emergency number for help.

Multiple Classes Of Pain Medication Use And Ckd

A common scenario where pain control is needed is with renal calculi. In developed countries the lifetime risk of kidney stones is 8%10% and this is higher in the elderly. Pain control of acute symptoms is accomplished with a combination of parenteral opioids and non-steroidal anti-inflammatory agents to maximize the benefits of both agents and limit doses of both to keep side effects at a minimum. The benefits of NSAIDS include a decrease of inflammation along the urinary tract. With AKI or peptic ulcer disease present, opioids may be the only option for renal colic despite being less effective with regard to inflammation . In this setting it is important to monitor for opioid side effects including confusion, respiratory depression, and urinary retention . While the burden of stone disease is problematic, the component of pain medications , dehydration and AKI are difficult to dissect.

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Epidemiology And Mechanism Of Action

The majority of opioids are metabolized through phase I biotransformation via CYP450 enzymes 2D6 and 3A4.2 Hepatic impairment is a condition that may lead to increased opioid toxicity. This occurrence is secondary to the parent drug being inadequately converted to the metabolite for elimination. Consideration of both the parent compound and metabolite accumulation should also be accounted for in patients with renal insufficiency.

According to Davidson and Jhangris study involving 205 patients on hemodialysis , up to one-half of patients receiving HD experienced chronic pain.3 Eighty-two percent of this patient population experienced moderate-to-severe pain, thereby justifying the need for stronger opioids.3 A total of 103 patients were experiencing chronic pain 26.2% of these chronic pain patients were prescribed weak opioids, while only 10% were given strong opioids.4 Hence, understanding opioid pharmacokinetics is imperative to adequately control pain and minimize toxicity and adverse effects.

Are There Any Potential Side Effects

Is acetaminophen bad for your kidneys ?

The most common side effects are sleepiness and constipation.

Other possible side effects include lack of appetite or vomiting. Serious side effects include collapse, severely decreased breathing rate, or decreased muscle movement. In cats, serious side effects also include increased excitement, tremors, and seizures.

This short-acting medication should stop working within 24 hours, although effects can be longer in pets with liver or kidney disease.

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Specialist Addiction Treatment Available At Priory

Priory has specialist treatment available for prescription drug addiction, where detoxification and psychotherapy are among the options available. If inpatient treatment is needed for medical detox or rehabilitation, our hospitals can offer 24-hour care and support in a safe, secure environment with private rooms. Co-existing mental health and physical symptoms will be assessed and treated so that recovery can happen as safely and comfortably as possible, while also helping to reduce the likelihood of relapse.

Our compassionate, caring specialists will offer state-of-the-art intensive therapy, which can include group, individual and family sessions. Priory also provides aftercare and maintenance support, to help connect you to a supporting community network.

This page was reviewed byDr Syed Omair Ahmed , Consultant Psychiatrist at The Priory Hospital Woodbourne

For details of how Priory can provide you with assistance regarding addiction treatment and rehabilitation, please call 0800 144 8969 or . For professionals looking to make a referral, please click here

What Are The Complications Of Analgesic Nephropathy

Some cases of acute kidney failure have been linked to the use of painkillers, including aspirin, ibuprofen, and naproxen. Many of these people had risk factors, such as:

  • Lupus
  • Chronic kidney conditions
  • Recent binge-drinking alcohol

Talk with your healthcare provider for more information about diagnosis and treatment of analgesic nephropathy and kidney failure.

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Pain Medication For People With Kidney Disease

The following information is also available as a downloadable leaflet:Pain medication for people with kidney disease

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Pain is one of the most common and distressing symptoms for people with chronic kidney disease . Take care when choosing a pain killer as some types should not be taken by people with kidney problems or should only be used with specialist guidance. When a pain killer is prescribed for you for either acute or chronic pain, a stepwise approach is used . This means that the weakest pain killer from the first step of the analgesic ladder is tried first. If you are still in pain, a stronger pain killer will be tried. Your pain and any side effects will be monitored closely.

This information explains the different types of pain killers recommended if you have kidney disease. This information is for older children and adults only.

What are the different types of painkillers?

The main types of pain killer are:

  • Paracetamol
  • Nonsteroidal anti-inflammatory drugs e.g. ibuprofen, naproxen
  • Weak opioids e.g. codeine, dihydrocodeine, tramadol
  • Strong opioids e.g. morphine, oxycodone, alfentanil
  • Others e.g. amitriptyline, gabapentin

The type of pain killer prescribed depends on how severe your pain is and where it is coming from.

What are the different types of pain killers?


Opioids Use Leading To Ckd

How to Give Codeine to Cats in Pain: 15 Steps (with Pictures)

Opioid use may result in CKD due to repeated episodes of AKI, toxin exposure, or infection. Toxin exposure as noted in heroin-associated nephropathy and chronic infections as in secondary amyloidosis from skin popping, or result in a chronic infection due to the mode of drug use that then results in CKD due to hepatitis or HIV.

Frequently, multiple drugs or toxins may be used and clinical presentation may include multi-organ pathology, especially in the setting of a long-acting opioid. Autopsy data comparing methodone to heroin toxicity deaths revealed more pre-existing pathology with methodone including cardiac , pulmonary , hepatic , and renal disease . Further, methodone toxicity deaths included more polypharmacy with bendiazepine use , but with less alcohol use .

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How To Find Treatment For Codeine Addiction

Addiction to Codeine or lean is a serious problem. If you or someone you know is struggling with Codeine addiction, please contact a dedicated treatment provider today to learn more about treatment centers which can help you or your loved one overcome Codeine abuse and begin to live a better life. The effects of Codeine are potentially fatal and you shouldnt wait for an overdose to start looking for help. If Codeine is disrupting your life, today could be the day to make a difference.


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